Osteopontin (P10923)

Uniprot ID P10923
Protein Name Osteopontin
Gene Name Spp1
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.704
Function Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
GO - Molecular function
  • cytokine activity : NAS:UniProtKB
  • extracellular matrix binding : IDA:MGI
GO - Biological process
  • androgen catabolic process : ISO:MGI
  • biomineral tissue development : IEA:UniProtKB-KW
  • cell adhesion : ISO:MGI
  • cellular response to fluid shear stress : IDA:MGI
  • cellular response to leukemia inhibitory factor : IEP:MGI
  • cellular response to testosterone stimulus : ISO:MGI
  • negative regulation of apoptotic process : NAS:UniProtKB
  • neutrophil chemotaxis : IDA:MGI
  • osteoblast differentiation : ISO:MGI
  • positive regulation of bone resorption : ISO:MGI
  • positive regulation of cell-substrate adhesion : IDA:MGI
  • positive regulation of estradiol secretion : ISO:MGI
  • positive regulation of transcription, DNA-templated : ISO:MGI
  • response to organic substance : ISO:MGI
  • response to steroid hormone : ISO:MGI
  • response to vitamin D : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.