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P10912

Growth hormone receptor (P10912)

Uniprot ID P10912
Protein Name Growth hormone receptor
Gene Name GHR
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.169
Function Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). .The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
GO - Molecular function
  • cytokine receptor activity : IEA:InterPro
  • growth factor binding : IPI:BHF-UCL
  • identical protein binding : IPI:IntAct
  • peptide hormone binding : IPI:BHF-UCL
  • proline-rich region binding : ISS:BHF-UCL
  • protein homodimerization activity : IDA:BHF-UCL
  • protein kinase binding : ISS:BHF-UCL
GO - Biological process
  • 2-oxoglutarate metabolic process : ISS:BHF-UCL
  • activation of Janus kinase activity : ISS:BHF-UCL
  • activation of MAPK activity : ISS:BHF-UCL
  • allantoin metabolic process : ISS:BHF-UCL
  • cellular response to hormone stimulus : IMP:BHF-UCL
  • citrate metabolic process : ISS:BHF-UCL
  • creatine metabolic process : ISS:BHF-UCL
  • creatinine metabolic process : ISS:BHF-UCL
  • endocytosis : IEA:UniProtKB-KW
  • fatty acid metabolic process : ISS:BHF-UCL
  • growth hormone receptor signaling pathway : IMP:BHF-UCL
  • hormone metabolic process : IMP:BHF-UCL
  • insulin-like growth factor receptor signaling pathway : IMP:BHF-UCL
  • isoleucine metabolic process : ISS:BHF-UCL
  • JAK-STAT cascade : ISS:BHF-UCL
  • JAK-STAT cascade involved in growth hormone signaling pathway : TAS:Reactome
  • oxaloacetate metabolic process : ISS:BHF-UCL
  • positive regulation of multicellular organism growth : IMP:BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation : ISS:BHF-UCL
  • positive regulation of tyrosine phosphorylation of STAT protein : ISS:BHF-UCL
  • receptor internalization : IDA:BHF-UCL
  • regulation of multicellular organism growth : ISS:BHF-UCL
  • response to cycloheximide : IDA:BHF-UCL
  • response to estradiol : IDA:BHF-UCL
  • succinate metabolic process : ISS:BHF-UCL
  • taurine metabolic process : ISS:BHF-UCL
  • valine metabolic process : ISS:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.