Signal peptide(a) |
Y |
Secretome P(b) |
0.918 |
Function |
Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils. |
GO - Molecular function |
- calcium-dependent protein kinase C activity : ISS:UniProtKB
- CCR chemokine receptor binding : IBA:GO_Central
- chemoattractant activity : ISS:UniProtKB
- chemokine activity : IDA:MGI
- kinase activity : ISS:UniProtKB
- phospholipase activator activity : ISS:UniProtKB
- protein kinase activity : ISS:UniProtKB
|
GO - Biological process |
- astrocyte cell migration : IDA:UniProtKB
- calcium ion transport : ISS:UniProtKB
- calcium-mediated signaling : ISS:UniProtKB
- cell activation : ISS:UniProtKB
- cell-cell signaling : ISS:UniProtKB
- cellular calcium ion homeostasis : ISS:UniProtKB
- cellular response to interferon-gamma : IBA:GO_Central
- cellular response to interleukin-1 : IBA:GO_Central
- cellular response to organic cyclic compound : ISS:UniProtKB
- cellular response to tumor necrosis factor : IBA:GO_Central
- chemokine-mediated signaling pathway : IBA:GO_Central
- chemotaxis : ISS:UniProtKB
- cytoskeleton organization : ISS:UniProtKB
- eosinophil chemotaxis : ISS:UniProtKB
- eosinophil degranulation : ISS:UniProtKB
- exocytosis : ISS:UniProtKB
- G-protein coupled receptor signaling pathway : IBA:GO_Central
- granulocyte chemotaxis : ISS:UniProtKB
- inflammatory response : ISS:UniProtKB
- leukocyte chemotaxis : ISO:MGI
- lipopolysaccharide-mediated signaling pathway : ISS:UniProtKB
- lymphocyte chemotaxis : ISS:UniProtKB
- macrophage chemotaxis : IGI:UniProtKB
- MAPK cascade : ISS:UniProtKB
- monocyte chemotaxis : ISS:UniProtKB
- negative regulation by host of viral transcription : ISS:UniProtKB
- negative regulation of gene expression : ISS:UniProtKB
- negative regulation of osteoclast differentiation : ISS:UniProtKB
- neutrophil chemotaxis : ISS:UniProtKB
- osteoblast differentiation : ISS:UniProtKB
- positive regulation of calcium ion transport : ISS:UniProtKB
- positive regulation of calcium-mediated signaling : ISS:UniProtKB
- positive regulation of cell migration : ISS:UniProtKB
- positive regulation of cytosolic calcium ion concentration : ISO:MGI
- positive regulation of ERK1 and ERK2 cascade : ISS:UniProtKB
- positive regulation of gene expression : ISS:UniProtKB
- positive regulation of GTPase activity : IBA:GO_Central
- positive regulation of inflammatory response : IGI:UniProtKB
- positive regulation of interleukin-1 beta secretion : IGI:UniProtKB
- positive regulation of natural killer cell chemotaxis : ISS:UniProtKB
- positive regulation of neuron apoptotic process : IGI:UniProtKB
- positive regulation of osteoclast differentiation : ISO:MGI
- positive regulation of transcription by RNA polymerase II : IMP:UniProtKB
- positive regulation of tumor necrosis factor production : IGI:UniProtKB
- protein kinase B signaling : ISS:UniProtKB
- protein phosphorylation : ISS:UniProtKB
- regulation of cell shape : IDA:UniProtKB
- regulation of sensory perception of pain : ISS:UniProtKB
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum : ISS:UniProtKB
- response to cholesterol : ISS:UniProtKB
- response to drug : IEA:Ensembl
- response to toxic substance : ISS:UniProtKB
- signaling : ISS:UniProtKB
- T cell chemotaxis : ISS:UniProtKB
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