Monocyte differentiation antigen CD14 (P10810)

Uniprot ID P10810
Protein Name Monocyte differentiation antigen CD14
Gene Name Cd14
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.729
Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:16148141). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135, PubMed:15895089). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). .
GO - Molecular function
  • lipopeptide binding : ISO:MGI
  • lipopolysaccharide binding : ISO:MGI
  • lipoteichoic acid binding : ISO:MGI
GO - Biological process
  • cellular response to diacyl bacterial lipopeptide : ISS:UniProtKB
  • cellular response to lipopolysaccharide : IMP:UniProtKB
  • cellular response to lipoteichoic acid : ISO:MGI
  • cellular response to molecule of bacterial origin : ISO:MGI
  • cellular response to triacyl bacterial lipopeptide : ISS:UniProtKB
  • inflammatory response : ISO:MGI
  • innate immune response : IEA:UniProtKB-KW
  • lipopolysaccharide-mediated signaling pathway : IMP:UniProtKB
  • positive regulation of cytokine secretion : ISO:MGI
  • positive regulation of endocytosis : IMP:UniProtKB
  • positive regulation of interferon-gamma production : IMP:UniProtKB
  • positive regulation of interleukin-8 secretion : ISO:MGI
  • positive regulation of NIK/NF-kappaB signaling : ISO:MGI
  • positive regulation of tumor necrosis factor production : IMP:UniProtKB
  • positive regulation of type I interferon production : IMP:CACAO
  • receptor-mediated endocytosis : IMP:CACAO
  • response to bacterium : IMP:UniProtKB
  • response to electrical stimulus : IEA:Ensembl
  • response to ethanol : IEA:Ensembl
  • response to heat : IEA:Ensembl
  • response to magnesium ion : IEA:Ensembl
  • response to molecule of bacterial origin : IDA:UniProtKB
  • response to tumor necrosis factor : ISO:MGI
  • toll-like receptor 4 signaling pathway : IMP:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.