C-C motif chemokine 2 (P10148)

Uniprot ID P10148
Protein Name C-C motif chemokine 2
Gene Name Ccl2
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.375
Function Chemotactic factor that attracts monocytes, but not neutrophils.
GO - Molecular function
  • CCR2 chemokine receptor binding : IPI:BHF-UCL
  • chemokine activity : ISO:MGI
  • cytokine activity : IDA:MGI
  • G-protein coupled receptor binding : IDA:MGI
  • heparin binding : ISO:MGI
GO - Biological process
  • aging : IEA:Ensembl
  • angiogenesis : TAS:BHF-UCL
  • animal organ regeneration : IEA:Ensembl
  • antimicrobial humoral immune response mediated by antimicrobial peptide : ISO:MGI
  • astrocyte cell migration : ISS:BHF-UCL
  • cellular calcium ion homeostasis : ISO:MGI
  • cellular response to ATP : IEA:Ensembl
  • cellular response to dexamethasone stimulus : IEA:Ensembl
  • cellular response to estradiol stimulus : IEA:Ensembl
  • cellular response to fatty acid : IEA:Ensembl
  • cellular response to glucose stimulus : IEA:Ensembl
  • cellular response to high density lipoprotein particle stimulus : IEA:Ensembl
  • cellular response to insulin stimulus : IEA:Ensembl
  • cellular response to interferon-gamma : IDA:BHF-UCL
  • cellular response to interleukin-1 : IDA:BHF-UCL
  • cellular response to interleukin-6 : IEA:Ensembl
  • cellular response to lipopolysaccharide : IDA:BHF-UCL
  • cellular response to macrophage colony-stimulating factor stimulus : IEA:Ensembl
  • cellular response to platelet-derived growth factor stimulus : IEA:Ensembl
  • cellular response to retinoic acid : IEA:Ensembl
  • cellular response to tumor necrosis factor : IDA:BHF-UCL
  • chemokine-mediated signaling pathway : ISO:MGI
  • chronic inflammatory response : IEA:Ensembl
  • cytokine-mediated signaling pathway : ISO:MGI
  • cytoskeleton organization : ISO:MGI
  • eosinophil chemotaxis : ISO:MGI
  • G-protein coupled receptor signaling pathway : IBA:GO_Central
  • glial cell migration : ISO:MGI
  • helper T cell extravasation : IDA:BHF-UCL
  • inflammatory response : IBA:GO_Central
  • killing of cells of other organism : ISO:MGI
  • leukocyte migration involved in inflammatory response : ISO:MGI
  • lymphocyte chemotaxis : ISO:MGI
  • macrophage chemotaxis : ISS:BHF-UCL
  • maternal process involved in female pregnancy : IEA:Ensembl
  • maternal process involved in parturition : IEA:Ensembl
  • monocyte homeostasis : TAS:BHF-UCL
  • negative regulation of angiogenesis : IMP:BHF-UCL
  • neutrophil chemotaxis : ISO:MGI
  • positive regulation of apoptotic cell clearance : IDA:BHF-UCL
  • positive regulation of cell adhesion : ISO:MGI
  • positive regulation of cell-cell adhesion : ISO:MGI
  • positive regulation of cellular extravasation : ISO:MGI
  • positive regulation of collagen biosynthetic process : ISO:MGI
  • positive regulation of endothelial cell proliferation : ISO:MGI
  • positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central
  • positive regulation of GTPase activity : IBA:GO_Central
  • positive regulation of immune complex clearance by monocytes and macrophages : IMP:BHF-UCL
  • positive regulation of leukocyte mediated cytotoxicity : ISO:MGI
  • positive regulation of leukocyte migration : ISO:MGI
  • positive regulation of macrophage chemotaxis : IDA:BHF-UCL
  • positive regulation of monocyte chemotaxis : IDA:UniProtKB
  • positive regulation of nitric-oxide synthase biosynthetic process : IMP:BHF-UCL
  • positive regulation of protein targeting to membrane : ISO:MGI
  • positive regulation of synaptic transmission : ISO:MGI
  • positive regulation of T cell activation : IMP:BHF-UCL
  • positive regulation of tumor necrosis factor production : ISO:MGI
  • positive regulation of wound healing : ISO:MGI
  • regulation of cell shape : ISO:MGI
  • regulation of vascular endothelial growth factor production : IMP:BHF-UCL
  • response to activity : IEA:Ensembl
  • response to amino acid : IEA:Ensembl
  • response to cyclosporin A : IEA:Ensembl
  • response to ethanol : IEA:Ensembl
  • response to gamma radiation : IEA:Ensembl
  • response to heat : ISO:MGI
  • response to hypoxia : IEA:Ensembl
  • response to mechanical stimulus : IEA:Ensembl
  • response to progesterone : IEA:Ensembl
  • response to vitamin B3 : IEA:Ensembl
  • response to wounding : IDA:MGI
  • transforming growth factor beta receptor signaling pathway : ISO:MGI
  • vascular endothelial growth factor receptor signaling pathway : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.