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P10126

Elongation factor 1-alpha 1 (P10126)

Uniprot ID P10126
Protein Name Elongation factor 1-alpha 1
Gene Name Eef1a1
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.213
Function This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. .
GO - Molecular function
  • calmodulin binding : IDA:CAFA
  • drug binding : ISO:MGI
  • GTP binding : IEA:UniProtKB-KW
  • GTPase activity : IBA:GO_Central
  • mRNA binding : ISO:MGI
  • protein kinase binding : ISO:MGI
  • translation elongation factor activity : IBA:GO_Central
  • tRNA binding : ISO:MGI
GO - Biological process
  • cellular response to epidermal growth factor stimulus : ISS:UniProtKB
  • negative regulation of reactive oxygen species biosynthetic process : ISO:MGI
  • positive regulation of cell death : ISO:MGI
  • positive regulation of neuron projection development : ISO:MGI
  • protein homooligomerization : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.