Signal peptide(a) |
N |
Secretome P(b) |
|
Function |
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. . |
GO - Molecular function |
- adenylate cyclase activator activity : ISO:RGD
- adenylate cyclase binding : IDA:RGD
- calcium channel inhibitor activity : ISS:UniProtKB
- calcium channel regulator activity : NAS:RGD
- calcium ion binding : IDA:RGD
- calcium-dependent protein binding : IPI:RGD
- disordered domain specific binding : ISO:RGD
- enzyme regulator activity : IBA:GO_Central
- ion channel binding : IDA:RGD
- N-terminal myristoylation domain binding : ISO:RGD
- nitric-oxide synthase binding : IDA:RGD
- nitric-oxide synthase regulator activity : IDA:RGD
- phosphatidylinositol 3-kinase binding : IPI:RGD
- protein domain specific binding : IPI:RGD
- protein kinase binding : ISO:RGD
- protein N-terminus binding : IDA:RGD
- protein phosphatase activator activity : ISO:RGD
- titin binding : ISO:RGD
- type 3 metabotropic glutamate receptor binding : IPI:RGD
|
GO - Biological process |
- activation of adenylate cyclase activity : IDA:RGD
- calcium-mediated signaling : IMP:RGD
- detection of calcium ion : ISO:RGD
- establishment of protein localization to membrane : IMP:CAFA
- establishment of protein localization to mitochondrial membrane : IMP:CAFA
- G2/M transition of mitotic cell cycle : ISO:RGD
- microtubule cytoskeleton organization : IBA:GO_Central
- negative regulation of ryanodine-sensitive calcium-release channel activity : ISS:UniProtKB
- positive regulation of cyclic-nucleotide phosphodiesterase activity : ISO:RGD
- positive regulation of DNA binding : ISO:RGD
- positive regulation of nitric-oxide synthase activity : IDA:RGD
- positive regulation of phosphoprotein phosphatase activity : ISO:RGD
- positive regulation of protein dephosphorylation : ISO:RGD
- positive regulation of ryanodine-sensitive calcium-release channel activity : ISO:RGD
- regulation of cardiac muscle contraction : ISO:RGD
- regulation of cytokinesis : ISO:RGD
- regulation of heart rate : ISO:RGD
- regulation of high voltage-gated calcium channel activity : IMP:RGD
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum : ISO:RGD
- regulation of ryanodine-sensitive calcium-release channel activity : IDA:RGD
- regulation of store-operated calcium channel activity : IC:RGD
- regulation of synaptic vesicle endocytosis : IMP:CAFA
- regulation of synaptic vesicle exocytosis : IMP:CAFA
- response to amphetamine : IEP:RGD
- response to calcium ion : ISO:RGD
|