| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). . |
| GO - Molecular function |
- adenylate cyclase activator activity : IDA:UniProtKB
- adenylate cyclase binding : IPI:CAFA
- calcium channel inhibitor activity : IDA:UniProtKB
- calcium ion binding : IDA:UniProtKB
- disordered domain specific binding : IPI:CAFA
- ion channel binding : IPI:BHF-UCL
- N-terminal myristoylation domain binding : IPI:UniProtKB
- protein domain specific binding : IPI:UniProtKB
- protein kinase binding : IPI:BHF-UCL
- protein phosphatase activator activity : IDA:BHF-UCL
- protein serine/threonine kinase activator activity : TAS:BHF-UCL
- titin binding : IPI:BHF-UCL
|
| GO - Biological process |
- calcium-mediated signaling : IBA:GO_Central
- detection of calcium ion : IMP:BHF-UCL
- G protein-coupled receptor signaling pathway : TAS:UniProtKB
- negative regulation of peptidyl-threonine phosphorylation : TAS:BHF-UCL
- negative regulation of ryanodine-sensitive calcium-release channel activity : IDA:UniProtKB
- positive regulation of cyclic-nucleotide phosphodiesterase activity : IDA:BHF-UCL
- positive regulation of peptidyl-threonine phosphorylation : TAS:BHF-UCL
- positive regulation of phosphoprotein phosphatase activity : IDA:BHF-UCL
- positive regulation of protein autophosphorylation : TAS:BHF-UCL
- positive regulation of protein dephosphorylation : IDA:BHF-UCL
- positive regulation of protein serine/threonine kinase activity : TAS:BHF-UCL
- positive regulation of ryanodine-sensitive calcium-release channel activity : IDA:BHF-UCL
- regulation of cardiac muscle contraction : IMP:BHF-UCL
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion : IC:BHF-UCL
- regulation of cell communication by electrical coupling involved in cardiac conduction : IC:BHF-UCL
- regulation of cytokinesis : IMP:UniProtKB
- regulation of heart rate : IMP:BHF-UCL
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum : IDA:BHF-UCL
- response to calcium ion : IDA:BHF-UCL
- substantia nigra development : HEP:UniProtKB
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