Interferon-activable protein 204 (P0DOV2)

Uniprot ID P0DOV2
Protein Name Interferon-activable protein 204
Gene Name Ifi204
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.0
Function Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation. .
GO - Molecular function
  • core promoter binding : ISO:MGI
  • double-stranded DNA binding : IDA:MGI
  • identical protein binding : ISO:MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding : ISO:MGI
  • transcription cofactor activity : IGI:MGI
  • transcription factor binding : ISO:MGI
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding : ISO:MGI
GO - Biological process
  • cellular response to interferon-alpha : IDA:UniProtKB
  • cellular response to interferon-beta : IDA:MGI
  • inner ear development : IDA:MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator : ISO:MGI
  • positive regulation of osteoblast differentiation : IGI:MGI
  • regulation of transcription by RNA polymerase II : IDA:MGI
  • transcription, DNA-templated : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.