Phosphatidylinositol phosphatase PTPRQ (P0C5E4)

Uniprot ID P0C5E4
Protein Name Phosphatidylinositol phosphatase PTPRQ
Gene Name Ptprq
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.3
Function Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells (By similarity). .
GO - Molecular function
  • protein tyrosine phosphatase activity : IEA:UniProtKB-EC
GO - Biological process
  • detection of mechanical stimulus involved in sensory perception of sound : IMP:MGI
  • hematopoietic progenitor cell differentiation : IMP:MGI
  • inner ear morphogenesis : IMP:MGI
  • neuromuscular process controlling balance : IMP:MGI
  • regulation of fat cell differentiation : ISS:UniProtKB
  • vestibular receptor cell morphogenesis : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.