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P0C1Q2

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (P0C1Q2)

Uniprot ID P0C1Q2
Protein Name Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Gene Name Pde11a
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b) 0.444
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity). .
GO - Molecular function
  • 3',5'-cyclic-GMP phosphodiesterase activity : IEA:UniProtKB-EC
  • cAMP binding : ISO:MGI
  • cGMP binding : ISS:UniProtKB
  • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity : ISS:UniProtKB
  • cyclic-nucleotide phosphodiesterase activity : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • cAMP catabolic process : ISO:MGI
  • cGMP catabolic process : ISO:MGI
  • signal transduction : IEA:InterPro
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.