Leucine-rich repeat-containing protein 4B (P0C192)

Uniprot ID P0C192
Protein Name Leucine-rich repeat-containing protein 4B
Gene Name Lrrc4b
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.1
Function Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). .
GO - Molecular function
  • protein kinase inhibitor activity : IBA:GO_Central
  • signaling receptor binding : IPI:BHF-UCL
GO - Biological process
  • cytokine-mediated signaling pathway : IBA:GO_Central
  • negative regulation of JAK-STAT cascade : IBA:GO_Central
  • negative regulation of protein kinase activity : IBA:GO_Central
  • positive regulation of synapse assembly : IDA:BHF-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.