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P0C0S6

Histone H2A.Z (P0C0S6)

Uniprot ID P0C0S6
Protein Name Histone H2A.Z
Gene Name H2afz
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.645
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development. .
GO - Molecular function
  • chromatin DNA binding : ISO:MGI
  • DNA binding : IBA:GO_Central
  • nucleosomal DNA binding : ISO:MGI
  • protein heterodimerization activity : IEA:InterPro
  • RNA polymerase II core promoter sequence-specific DNA binding : ISO:MGI
  • RNA polymerase II distal enhancer sequence-specific DNA binding : ISO:MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding : ISO:MGI
GO - Biological process
  • cellular response to estradiol stimulus : ISO:MGI
  • cellular response to insulin stimulus : ISO:MGI
  • chromatin silencing : IBA:GO_Central
  • multicellular organism development : IEA:UniProtKB-KW
  • positive regulation of transcription by RNA polymerase II : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.