| Signal peptide(a) |
Y |
Secretome P(b) |
0.892 |
| Function |
The insulin-like growth factors possess growth-promoting activity (Probable). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed:2330056, PubMed:12087403). IGF-II is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed:16901893). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). .Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. {ECO:0000269|PubMed:16912056}. |
| GO - Molecular function |
- growth factor activity : ISO:MGI
- hormone activity : IEA:UniProtKB-KW
- insulin receptor binding : ISO:MGI
- insulin-like growth factor receptor binding : IPI:MGI
- integrin binding : ISS:UniProtKB
- protein serine/threonine kinase activator activity : IMP:BHF-UCL
- receptor ligand activity : IMP:BHF-UCL
|
| GO - Biological process |
- animal organ morphogenesis : IMP:MGI
- embryonic placenta development : IMP:UniProtKB
- embryonic placenta morphogenesis : IMP:UniProtKB
- exocrine pancreas development : IMP:MGI
- glucose metabolic process : IEA:UniProtKB-KW
- in utero embryonic development : IMP:UniProtKB
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase : IMP:BHF-UCL
- memory : ISO:MGI
- negative regulation of natural killer cell mediated cytotoxicity : ISO:MGI
- negative regulation of transcription by RNA polymerase II : IMP:UniProtKB
- osteoblast differentiation : IEP:BHF-UCL
- positive regulation of activated T cell proliferation : ISO:MGI
- positive regulation of angiogenesis : ISO:MGI
- positive regulation of blood vessel endothelial cell migration : ISO:MGI
- positive regulation of catalytic activity : IMP:BHF-UCL
- positive regulation of cell division : IEA:UniProtKB-KW
- positive regulation of cell proliferation : ISS:UniProtKB
- positive regulation of glycogen (starch) synthase activity : IMP:BHF-UCL
- positive regulation of glycogen biosynthetic process : IMP:BHF-UCL
- positive regulation of insulin receptor signaling pathway : IMP:BHF-UCL
- positive regulation of MAPK cascade : ISO:MGI
- positive regulation of mitotic nuclear division : ISO:MGI
- positive regulation of multicellular organism growth : IMP:MGI
- positive regulation of peptidyl-tyrosine phosphorylation : IMP:BHF-UCL
- positive regulation of protein kinase B signaling : ISO:MGI
- positive regulation of protein phosphorylation : IMP:BHF-UCL
- positive regulation of steroid hormone biosynthetic process : ISO:MGI
- positive regulation of transcription by RNA polymerase II : IGI:MGI
- positive regulation of vascular endothelial cell proliferation : ISO:MGI
- regulation of histone modification : IMP:UniProtKB
- regulation of muscle cell differentiation : IMP:UniProtKB
- response to drug : ISO:MGI
- response to nicotine : ISO:MGI
- response to organic cyclic compound : ISO:MGI
- striated muscle cell differentiation : IGI:MGI
|