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P09496

Clathrin light chain A (P09496)

Uniprot ID P09496
Protein Name Clathrin light chain A
Gene Name CLTA
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.927
Function Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). .
GO - Molecular function
  • clathrin heavy chain binding : IPI:FlyBase
  • GTPase binding : IEA:Ensembl
  • peptide binding : IEA:Ensembl
  • protein-containing complex binding : IEA:Ensembl
  • structural molecule activity : IBA:GO_Central
GO - Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II : TAS:Reactome
  • cell cycle : IEA:UniProtKB-KW
  • cell division : IEA:UniProtKB-KW
  • clathrin coat assembly : IMP:CAFA
  • clathrin-dependent endocytosis : IBA:GO_Central
  • intracellular protein transport : IEA:InterPro
  • low-density lipoprotein particle clearance : TAS:Reactome
  • low-density lipoprotein particle receptor catabolic process : TAS:Reactome
  • membrane organization : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.