Tropomyosin alpha-4 chain (P09495)

Uniprot ID P09495
Protein Name Tropomyosin alpha-4 chain
Gene Name Tpm4
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Binds to actin filaments in muscle and non-muscle cells (PubMed:7568216). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (By similarity). Smooth muscle contraction is regulated by interaction with caldesmon (By similarity). In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (By similarity). .
GO - Molecular function
  • actin filament binding : IDA:UniProtKB
  • identical protein binding : IDA:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
  • protein heterodimerization activity : IDA:UniProtKB
  • protein homodimerization activity : IDA:UniProtKB
GO - Biological process
  • actin filament organization : IBA:GO_Central
  • muscle contraction : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.