Signal peptide(a) |
N |
Secretome P(b) |
0.599 |
Function |
Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
GO - Molecular function |
- actin binding : TAS:BHF-UCL
- actin filament binding : ISS:UniProtKB
- cytoskeletal protein binding : IPI:UniProtKB
- identical protein binding : ISS:UniProtKB
- protein heterodimerization activity : ISS:UniProtKB
- protein homodimerization activity : ISS:UniProtKB
- structural constituent of cytoskeleton : TAS:BHF-UCL
- structural constituent of muscle : TAS:ProtInc
|
GO - Biological process |
- actin filament organization : IBA:GO_Central
- cardiac muscle contraction : IMP:BHF-UCL
- cellular response to reactive oxygen species : IEP:BHF-UCL
- cytoskeleton organization : TAS:BHF-UCL
- in utero embryonic development : IEA:Ensembl
- muscle contraction : IBA:GO_Central
- muscle filament sliding : ISS:BHF-UCL
- negative regulation of cell migration : ISS:BHF-UCL
- negative regulation of vascular associated smooth muscle cell migration : IMP:BHF-UCL
- negative regulation of vascular smooth muscle cell proliferation : IMP:BHF-UCL
- positive regulation of ATPase activity : ISS:BHF-UCL
- positive regulation of cell adhesion : ISS:BHF-UCL
- positive regulation of heart rate by epinephrine : ISS:BHF-UCL
- positive regulation of stress fiber assembly : ISS:BHF-UCL
- regulation of cell shape : IMP:BHF-UCL
- regulation of heart contraction : TAS:ProtInc
- regulation of muscle contraction : TAS:ProtInc
- ruffle organization : ISS:BHF-UCL
- sarcomere organization : IMP:BHF-UCL
- ventricular cardiac muscle tissue morphogenesis : IMP:BHF-UCL
- wound healing : ISS:BHF-UCL
|