Tropomyosin alpha-1 chain (P09493)

Uniprot ID P09493
Protein Name Tropomyosin alpha-1 chain
Gene Name TPM1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.599
Function Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
GO - Molecular function
  • actin binding : TAS:BHF-UCL
  • actin filament binding : ISS:UniProtKB
  • cytoskeletal protein binding : IPI:UniProtKB
  • identical protein binding : ISS:UniProtKB
  • protein heterodimerization activity : ISS:UniProtKB
  • protein homodimerization activity : ISS:UniProtKB
  • structural constituent of cytoskeleton : TAS:BHF-UCL
  • structural constituent of muscle : TAS:ProtInc
GO - Biological process
  • actin filament organization : IBA:GO_Central
  • cardiac muscle contraction : IMP:BHF-UCL
  • cellular response to reactive oxygen species : IEP:BHF-UCL
  • cytoskeleton organization : TAS:BHF-UCL
  • in utero embryonic development : IEA:Ensembl
  • muscle contraction : IBA:GO_Central
  • muscle filament sliding : ISS:BHF-UCL
  • negative regulation of cell migration : ISS:BHF-UCL
  • negative regulation of vascular associated smooth muscle cell migration : IMP:BHF-UCL
  • negative regulation of vascular smooth muscle cell proliferation : IMP:BHF-UCL
  • positive regulation of ATPase activity : ISS:BHF-UCL
  • positive regulation of cell adhesion : ISS:BHF-UCL
  • positive regulation of heart rate by epinephrine : ISS:BHF-UCL
  • positive regulation of stress fiber assembly : ISS:BHF-UCL
  • regulation of cell shape : IMP:BHF-UCL
  • regulation of heart contraction : TAS:ProtInc
  • regulation of muscle contraction : TAS:ProtInc
  • ruffle organization : ISS:BHF-UCL
  • sarcomere organization : IMP:BHF-UCL
  • ventricular cardiac muscle tissue morphogenesis : IMP:BHF-UCL
  • wound healing : ISS:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.