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P09486

SPARC (P09486)

Uniprot ID P09486
Protein Name SPARC
Gene Name SPARC
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.904
Function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
GO - Molecular function
  • calcium ion binding : IDA:UniProtKB
  • collagen binding : IDA:UniProtKB
  • extracellular matrix binding : IBA:GO_Central
GO - Biological process
  • anatomical structure development : IBA:GO_Central
  • bone development : IEA:Ensembl
  • cellular response to growth factor stimulus : IEA:Ensembl
  • extracellular matrix organization : TAS:Reactome
  • heart development : IEA:Ensembl
  • inner ear development : IEA:Ensembl
  • lung development : IEA:Ensembl
  • negative regulation of angiogenesis : IDA:UniProtKB
  • negative regulation of endothelial cell proliferation : IDA:UniProtKB
  • ossification : IEA:Ensembl
  • pigmentation : IEA:Ensembl
  • platelet degranulation : TAS:Reactome
  • positive regulation of endothelial cell migration : IDA:UniProtKB
  • receptor-mediated endocytosis : TAS:Reactome
  • regulation of cell morphogenesis : IDA:UniProtKB
  • regulation of synapse organization : IEA:Ensembl
  • response to cadmium ion : IEA:Ensembl
  • response to calcium ion : IEA:Ensembl
  • response to cAMP : IEA:Ensembl
  • response to cytokine : IEA:Ensembl
  • response to ethanol : IEA:Ensembl
  • response to glucocorticoid : IEA:Ensembl
  • response to gravity : IEA:Ensembl
  • response to L-ascorbic acid : IEA:Ensembl
  • response to lead ion : IEA:Ensembl
  • response to lipopolysaccharide : IEA:Ensembl
  • response to peptide hormone : IEA:Ensembl
  • wound healing : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.