Nucleolin (P09405)

Uniprot ID P09405
Protein Name Nucleolin
Gene Name Ncl
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.358
Function Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). .
GO - Molecular function
  • calcium ion binding : ISO:MGI
  • DNA topoisomerase binding : ISO:MGI
  • ErbB-4 class receptor binding : ISO:MGI
  • histone binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • laminin binding : ISO:MGI
  • mRNA 5'-UTR binding : ISO:MGI
  • protein C-terminus binding : ISO:MGI
  • RNA binding : IDA:MGI
  • rRNA primary transcript binding : ISO:MGI
  • selenocysteine insertion sequence binding : ISO:MGI
  • sequence-specific DNA binding : ISO:MGI
  • signaling receptor binding : ISO:MGI
  • single-stranded DNA binding : ISO:MGI
  • telomeric DNA binding : ISS:UniProtKB
GO - Biological process
  • angiogenesis : ISO:MGI
  • cellular response to epidermal growth factor stimulus : IDA:MGI
  • cellular response to leukemia inhibitory factor : IEP:MGI
  • cellular response to lipopolysaccharide : ISO:MGI
  • endocytosis : ISO:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of translation : ISO:MGI
  • positive regulation of interleukin-6 secretion : ISO:MGI
  • positive regulation of transcription by RNA polymerase II : IGI:MGI
  • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I : ISO:MGI
  • positive regulation of tumor necrosis factor production : ISO:MGI
  • regulation of rRNA processing : ISO:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.