| Signal peptide(a) |
N |
Secretome P(b) |
0.358 |
| Function |
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). . |
| GO - Molecular function |
- calcium ion binding : ISO:MGI
- DNA topoisomerase binding : ISO:MGI
- ErbB-4 class receptor binding : ISO:MGI
- histone binding : ISO:MGI
- identical protein binding : ISO:MGI
- laminin binding : ISO:MGI
- mRNA 5'-UTR binding : ISO:MGI
- protein C-terminus binding : ISO:MGI
- RNA binding : IDA:MGI
- rRNA primary transcript binding : ISO:MGI
- selenocysteine insertion sequence binding : ISO:MGI
- sequence-specific DNA binding : ISO:MGI
- signaling receptor binding : ISO:MGI
- single-stranded DNA binding : ISO:MGI
- telomeric DNA binding : ISS:UniProtKB
|
| GO - Biological process |
- angiogenesis : ISO:MGI
- cellular response to epidermal growth factor stimulus : IDA:MGI
- cellular response to leukemia inhibitory factor : IEP:MGI
- cellular response to lipopolysaccharide : ISO:MGI
- endocytosis : ISO:MGI
- negative regulation of apoptotic process : ISO:MGI
- negative regulation of translation : ISO:MGI
- positive regulation of interleukin-6 secretion : ISO:MGI
- positive regulation of transcription by RNA polymerase II : IGI:MGI
- positive regulation of transcription of nucleolar large rRNA by RNA polymerase I : ISO:MGI
- positive regulation of tumor necrosis factor production : ISO:MGI
- regulation of rRNA processing : ISO:MGI
|