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P09341

Growth-regulated alpha protein (P09341)

Uniprot ID P09341
Protein Name Growth-regulated alpha protein
Gene Name CXCL1
Species Homo sapiens (Human)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.659
Function Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. .
GO - Molecular function
  • chemokine activity : IBA:GO_Central
  • CXCR chemokine receptor binding : IBA:GO_Central
  • enzyme activator activity : TAS:ProtInc
  • growth factor activity : IEA:UniProtKB-KW
  • signaling receptor binding : TAS:ProtInc
GO - Biological process
  • actin cytoskeleton organization : TAS:ProtInc
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
  • cell proliferation : TAS:ProtInc
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • chemotaxis : TAS:ProtInc
  • cytokine-mediated signaling pathway : TAS:Reactome
  • G-protein coupled receptor signaling pathway : TAS:Reactome
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • intracellular signal transduction : TAS:ProtInc
  • killing of cells of other organism : IDA:UniProtKB
  • negative regulation of cell proliferation : TAS:ProtInc
  • nervous system development : TAS:ProtInc
  • neutrophil degranulation : TAS:Reactome
  • positive regulation of neutrophil chemotaxis : IBA:GO_Central
  • response to lipopolysaccharide : IBA:GO_Central
  • signal transduction : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.