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P08752

Guanine nucleotide-binding protein G(i) subunit alpha-2 (P08752)

Uniprot ID P08752
Protein Name Guanine nucleotide-binding protein G(i) subunit alpha-2
Gene Name Gnai2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.651
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
GO - Molecular function
  • G-protein beta/gamma-subunit complex binding : IBA:GO_Central
  • G-protein coupled receptor binding : IBA:GO_Central
  • GTP binding : ISA:MGI
  • GTPase activity : IBA:GO_Central
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • activation of MAPKK activity : ISO:MGI
  • adenosine receptor signaling pathway : ISO:MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway : ISO:MGI
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway : IMP:MGI
  • cell cycle : IEA:UniProtKB-KW
  • cell division : ISS:UniProtKB
  • cell proliferation : IPI:MGI
  • G-protein coupled acetylcholine receptor signaling pathway : IMP:MGI
  • G-protein coupled receptor signaling pathway : ISO:MGI
  • gamma-aminobutyric acid signaling pathway : ISO:MGI
  • intracellular signal transduction : ISO:MGI
  • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process : ISO:MGI
  • negative regulation of apoptotic signaling pathway : ISO:MGI
  • negative regulation of calcium ion-dependent exocytosis : ISO:MGI
  • negative regulation of protein tyrosine phosphatase activity : ISO:MGI
  • negative regulation of synaptic transmission : ISO:MGI
  • positive regulation of cell migration : ISO:MGI
  • positive regulation of cell proliferation : ISO:MGI
  • positive regulation of ERK1 and ERK2 cascade : IEA:Ensembl
  • positive regulation of insulin receptor signaling pathway : ISO:MGI
  • positive regulation of NAD(P)H oxidase activity : ISO:MGI
  • positive regulation of neural precursor cell proliferation : ISO:MGI
  • positive regulation of renal sodium excretion : ISO:MGI
  • positive regulation of superoxide anion generation : ISO:MGI
  • positive regulation of urine volume : ISO:MGI
  • positive regulation of vascular smooth muscle cell proliferation : ISO:MGI
  • regulation of calcium ion transport : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.