Coagulation factor VII (P08709)

Uniprot ID P08709
Protein Name Coagulation factor VII
Gene Name F7
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.586
Function Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • serine-type endopeptidase activity : TAS:ProtInc
  • serine-type peptidase activity : TAS:ProtInc
  • signaling receptor binding : IEA:Ensembl
GO - Biological process
  • animal organ regeneration : IEA:Ensembl
  • blood coagulation : IDA:BHF-UCL
  • blood coagulation, extrinsic pathway : TAS:Reactome
  • circadian rhythm : IEA:Ensembl
  • endoplasmic reticulum to Golgi vesicle-mediated transport : TAS:Reactome
  • positive regulation of blood coagulation : IEA:Ensembl
  • positive regulation of cell migration : TAS:BHF-UCL
  • positive regulation of leukocyte chemotaxis : IDA:BHF-UCL
  • positive regulation of platelet-derived growth factor receptor signaling pathway : IDA:BHF-UCL
  • positive regulation of positive chemotaxis : IDA:BHF-UCL
  • positive regulation of protein kinase B signaling : IDA:BHF-UCL
  • protein processing : IDA:BHF-UCL
  • response to 2,3,7,8-tetrachlorodibenzodioxine : IEA:Ensembl
  • response to astaxanthin : IEA:Ensembl
  • response to carbon dioxide : IEA:Ensembl
  • response to cholesterol : IEA:Ensembl
  • response to estradiol : IEA:Ensembl
  • response to estrogen : IEA:Ensembl
  • response to genistein : IEA:Ensembl
  • response to growth hormone : IEA:Ensembl
  • response to hypoxia : IEA:Ensembl
  • response to Thyroid stimulating hormone : IEA:Ensembl
  • response to thyrotropin-releasing hormone : IEA:Ensembl
  • response to thyroxine : IEA:Ensembl
  • response to vitamin K : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.