Collagen alpha-2(IV) chain (P08572)

Uniprot ID P08572
Protein Name Collagen alpha-2(IV) chain
Gene Name COL4A2
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.076
Function Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
GO - Molecular function
  • extracellular matrix structural constituent : TAS:UniProtKB
GO - Biological process
  • aging : IEA:Ensembl
  • angiogenesis : IEA:UniProtKB-KW
  • cellular response to transforming growth factor beta stimulus : IEA:Ensembl
  • collagen-activated tyrosine kinase receptor signaling pathway : IEA:Ensembl
  • endodermal cell differentiation : IEP:UniProtKB
  • extracellular matrix organization : TAS:Reactome
  • negative regulation of angiogenesis : IDA:UniProtKB
  • response to activity : IEA:Ensembl
  • transcription, DNA-templated : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.