Superoxide dismutase [Cu-Zn] (P08228)

Uniprot ID P08228
Protein Name Superoxide dismutase [Cu-Zn]
Gene Name Sod1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.905
Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
GO - Molecular function
  • chaperone binding : ISS:UniProtKB
  • copper ion binding : ISS:UniProtKB
  • enzyme binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • protein phosphatase 2B binding : ISS:UniProtKB
  • Rac GTPase binding : ISO:MGI
  • superoxide dismutase activity : IDA:MGI
  • zinc ion binding : ISS:UniProtKB
GO - Biological process
  • activation of MAPK activity : IDA:MGI
  • aging : IMP:MGI
  • anterograde axonal transport : IMP:BHF-UCL
  • auditory receptor cell stereocilium organization : IMP:MGI
  • cell aging : ISO:MGI
  • cellular iron ion homeostasis : IMP:MGI
  • cellular response to ATP : IEA:Ensembl
  • cellular response to cadmium ion : IEA:Ensembl
  • cellular response to potassium ion : IEA:Ensembl
  • embryo implantation : IMP:MGI
  • glutathione metabolic process : IMP:MGI
  • heart contraction : IMP:MGI
  • hydrogen peroxide biosynthetic process : IMP:MGI
  • locomotory behavior : IMP:MGI
  • muscle cell cellular homeostasis : IMP:MGI
  • myeloid cell homeostasis : IMP:MGI
  • negative regulation of apoptotic process : IDA:MGI
  • negative regulation of cholesterol biosynthetic process : ISS:UniProtKB
  • negative regulation of neuron apoptotic process : IMP:MGI
  • neurofilament cytoskeleton organization : IMP:MGI
  • ovarian follicle development : IMP:MGI
  • peripheral nervous system myelin maintenance : IMP:MGI
  • positive regulation of catalytic activity : ISS:UniProtKB
  • positive regulation of cytokine production : ISS:UniProtKB
  • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway : ISO:MGI
  • positive regulation of superoxide anion generation : ISO:MGI
  • reactive oxygen species metabolic process : ISS:UniProtKB
  • regulation of blood pressure : IMP:MGI
  • regulation of GTPase activity : ISO:MGI
  • regulation of mitochondrial membrane potential : ISS:UniProtKB
  • regulation of multicellular organism growth : IMP:MGI
  • regulation of protein kinase activity : ISS:UniProtKB
  • relaxation of vascular smooth muscle : IMP:MGI
  • removal of superoxide radicals : IMP:MGI
  • response to amphetamine : IEA:Ensembl
  • response to antipsychotic drug : IEA:Ensembl
  • response to axon injury : IMP:MGI
  • response to carbon monoxide : IEA:Ensembl
  • response to copper ion : ISO:MGI
  • response to drug : IMP:MGI
  • response to ethanol : IMP:MGI
  • response to heat : IMP:MGI
  • response to hydrogen peroxide : IMP:MGI
  • response to nutrient levels : ISO:MGI
  • response to organic substance : ISS:UniProtKB
  • response to oxidative stress : IDA:MGI
  • response to reactive oxygen species : IMP:MGI
  • response to superoxide : IMP:MGI
  • retina homeostasis : IMP:MGI
  • retrograde axonal transport : IMP:BHF-UCL
  • sensory perception of sound : IMP:MGI
  • spermatogenesis : IMP:MGI
  • superoxide anion generation : IDA:MGI
  • superoxide metabolic process : IMP:MGI
  • transmission of nerve impulse : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.