| Signal peptide(a) |
Y |
Secretome P(b) |
0.92 |
| Function |
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. . |
| GO - Molecular function |
- amyloid-beta binding : ISS:UniProtKB
- antioxidant activity : ISO:MGI
- cholesterol binding : IBA:GO_Central
- cholesterol transporter activity : IDA:MGI
- heparin binding : ISO:MGI
- hydroxyapatite binding : ISO:MGI
- identical protein binding : ISO:MGI
- lipid binding : ISO:MGI
- lipid transporter activity : ISO:MGI
- lipoprotein particle binding : IDA:MGI
- low-density lipoprotein particle receptor binding : ISO:MGI
- metal chelating activity : ISO:MGI
- phosphatidylcholine-sterol O-acyltransferase activator activity : IMP:BHF-UCL
- phospholipid binding : ISO:MGI
- protein dimerization activity : ISO:MGI
- protein homodimerization activity : ISO:MGI
- signaling receptor binding : ISO:MGI
- tau protein binding : ISO:MGI
- very-low-density lipoprotein particle receptor binding : ISO:MGI
|
| GO - Biological process |
- aging : ISO:MGI
- AMPA glutamate receptor clustering : ISO:MGI
- amyloid precursor protein metabolic process : ISO:MGI
- artery morphogenesis : IGI:MGI
- cardiovascular system development : IMP:MGI
- cellular calcium ion homeostasis : IDA:MGI
- cGMP-mediated signaling : ISO:MGI
- cholesterol biosynthetic process : IBA:GO_Central
- cholesterol catabolic process : IMP:MGI
- cholesterol efflux : IDA:MGI
- cholesterol homeostasis : IMP:BHF-UCL
- cholesterol metabolic process : IMP:MGI
- chylomicron remnant clearance : ISO:MGI
- fatty acid homeostasis : ISO:MGI
- G-protein coupled receptor signaling pathway : ISO:MGI
- high-density lipoprotein particle assembly : ISO:MGI
- high-density lipoprotein particle clearance : ISO:MGI
- high-density lipoprotein particle remodeling : ISO:MGI
- lipid homeostasis : IMP:MGI
- lipid metabolic process : IGI:MGI
- lipid transport : ISO:MGI
- lipid transport involved in lipid storage : IMP:BHF-UCL
- lipoprotein biosynthetic process : IGI:MGI
- lipoprotein catabolic process : IMP:MGI
- lipoprotein metabolic process : IMP:MGI
- locomotory exploration behavior : ISO:MGI
- long-chain fatty acid transport : ISO:MGI
- long-term memory : ISO:MGI
- low-density lipoprotein particle remodeling : IMP:BHF-UCL
- maintenance of location in cell : IMP:MGI
- negative regulation of amyloid-beta formation : ISO:MGI
- negative regulation of blood coagulation : ISO:MGI
- negative regulation of blood vessel endothelial cell migration : ISO:MGI
- negative regulation of canonical Wnt signaling pathway : ISO:MGI
- negative regulation of cellular protein metabolic process : ISO:MGI
- negative regulation of cholesterol biosynthetic process : ISO:MGI
- negative regulation of endothelial cell proliferation : ISO:MGI
- negative regulation of gene expression : IMP:ARUK-UCL
- negative regulation of inflammatory response : IGI:UniProtKB
- negative regulation of long-term synaptic potentiation : ISO:MGI
- negative regulation of MAP kinase activity : ISO:MGI
- negative regulation of neuron apoptotic process : ISO:MGI
- negative regulation of neuron death : ISO:MGI
- negative regulation of neuron projection development : ISO:MGI
- negative regulation of platelet activation : ISO:MGI
- negative regulation of presynaptic membrane organization : ISO:MGI
- negative regulation of triglyceride metabolic process : IGI:MGI
- neuron projection regeneration : IBA:GO_Central
- nitric oxide mediated signal transduction : ISO:MGI
- NMDA glutamate receptor clustering : ISO:MGI
- phospholipid efflux : ISO:MGI
- positive regulation by host of viral process : ISO:MGI
- positive regulation of axon extension : ISO:MGI
- positive regulation of cGMP biosynthetic process : ISO:MGI
- positive regulation of cholesterol efflux : ISO:MGI
- positive regulation of cholesterol esterification : IMP:BHF-UCL
- positive regulation of dendritic spine development : ISO:MGI
- positive regulation of dendritic spine maintenance : ISO:MGI
- positive regulation of endocytosis : ISO:MGI
- positive regulation of heparan sulfate binding : ISO:MGI
- positive regulation of heparan sulfate proteoglycan binding : ISO:MGI
- positive regulation of lipid biosynthetic process : ISO:MGI
- positive regulation of lipid transport across blood brain barrier : ISO:MGI
- positive regulation of low-density lipoprotein particle receptor catabolic process : ISO:MGI
- positive regulation of membrane protein ectodomain proteolysis : ISO:MGI
- positive regulation of neuron projection development : IMP:ARUK-UCL
- positive regulation of nitric-oxide synthase activity : ISO:MGI
- positive regulation of phospholipid efflux : ISO:MGI
- positive regulation of postsynaptic membrane organization : ISO:MGI
- protein import : ISO:MGI
- receptor-mediated endocytosis : ISO:MGI
- regulation of amyloid fibril formation : ISO:MGI
- regulation of amyloid-beta clearance : ISO:MGI
- regulation of axon extension : IBA:GO_Central
- regulation of behavioral fear response : ISO:MGI
- regulation of Cdc42 protein signal transduction : ISO:MGI
- regulation of cellular response to very-low-density lipoprotein particle stimulus : ISO:MGI
- regulation of cholesterol metabolic process : ISO:MGI
- regulation of cholesterol transport : IBA:GO_Central
- regulation of gene expression : IMP:MGI
- regulation of plasma lipoprotein particle levels : IMP:BHF-UCL
- regulation of protein homooligomerization : ISO:MGI
- regulation of protein metabolic process : ISO:MGI
- regulation of triglyceride metabolic process : ISO:MGI
- response to caloric restriction : ISO:MGI
- response to dietary excess : IMP:MGI
- response to oxidative stress : IMP:MGI
- reverse cholesterol transport : ISO:MGI
- triglyceride catabolic process : IBA:GO_Central
- triglyceride homeostasis : IMP:BHF-UCL
- triglyceride metabolic process : ISO:MGI
- vasodilation : IMP:MGI
- very-low-density lipoprotein particle clearance : ISO:MGI
- very-low-density lipoprotein particle remodeling : IMP:BHF-UCL
- virion assembly : ISO:MGI
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