Endoplasmin (P08113)

Uniprot ID P08113
Protein Name Endoplasmin
Gene Name Hsp90b1
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.227
Function Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • low-density lipoprotein particle receptor binding : ISO:MGI
  • protein phosphatase binding : ISO:MGI
  • RNA binding : ISO:MGI
  • unfolded protein binding : IEA:InterPro
GO - Biological process
  • actin rod assembly : ISO:MGI
  • cellular response to ATP : ISO:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • protein folding : IEA:InterPro
  • regulation of phosphoprotein phosphatase activity : ISO:MGI
  • response to hypoxia : ISO:MGI
  • retrograde protein transport, ER to cytosol : ISO:MGI
  • ubiquitin-dependent ERAD pathway : ISS:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.