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P08030

Adenine phosphoribosyltransferase (P08030)

Uniprot ID P08030
Protein Name Adenine phosphoribosyltransferase
Gene Name Aprt
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (15) Interactions
Signal peptide(a) N Secretome P(b) 0.702
Function Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
GO - Molecular function
  • adenine binding : IDA:MGI
  • adenine phosphoribosyltransferase activity : IDA:MGI
  • AMP binding : ISO:MGI
GO - Biological process
  • adenine metabolic process : IMP:MGI
  • adenine salvage : IMP:MGI
  • AMP salvage : IEA:UniProtKB-UniPathway
  • cellular response to insulin stimulus : IEA:Ensembl
  • grooming behavior : IGI:MGI
  • lactation : ISO:MGI
  • purine ribonucleoside salvage : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.