| Signal peptide(a) |
N |
Secretome P(b) |
0.499 |
| Function |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). . |
| GO - Molecular function |
- calcium ion binding : NAS:BHF-UCL
- collagen V binding : IDA:BHF-UCL
- extracellular matrix structural constituent : HDA:BHF-UCL
- fibrinogen binding : IDA:BHF-UCL
- fibroblast growth factor binding : IDA:BHF-UCL
- fibronectin binding : IDA:BHF-UCL
- heparin binding : IDA:BHF-UCL
- identical protein binding : NAS:BHF-UCL
- integrin binding : IMP:BHF-UCL
- laminin binding : IDA:BHF-UCL
- low-density lipoprotein particle binding : IDA:BHF-UCL
- phosphatidylserine binding : IDA:UniProtKB
- proteoglycan binding : TAS:BHF-UCL
- transforming growth factor beta binding : ISS:BHF-UCL
|
| GO - Biological process |
- activation of MAPK activity : IMP:BHF-UCL
- behavioral response to pain : ISS:UniProtKB
- cell adhesion : NAS:BHF-UCL
- cell cycle arrest : IDA:BHF-UCL
- cell migration : IDA:BHF-UCL
- cellular response to growth factor stimulus : IEA:Ensembl
- cellular response to heat : NAS:BHF-UCL
- cellular response to tumor necrosis factor : IEA:Ensembl
- chronic inflammatory response : IEP:BHF-UCL
- engulfment of apoptotic cell : IDA:BHF-UCL
- extracellular matrix organization : TAS:Reactome
- immune response : IEP:BHF-UCL
- inflammatory response : IDA:CACAO
- negative regulation of angiogenesis : IDA:UniProtKB
- negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II : IDA:BHF-UCL
- negative regulation of apoptotic process : IDA:UniProtKB
- negative regulation of blood vessel endothelial cell migration : IDA:BHF-UCL
- negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis : IMP:BHF-UCL
- negative regulation of cell migration involved in sprouting angiogenesis : IMP:BHF-UCL
- negative regulation of cell-matrix adhesion : IDA:BHF-UCL
- negative regulation of cGMP-mediated signaling : IDA:BHF-UCL
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : IDA:UniProtKB
- negative regulation of dendritic cell antigen processing and presentation : IDA:BHF-UCL
- negative regulation of endothelial cell chemotaxis : IDA:MGI
- negative regulation of endothelial cell migration : IDA:BHF-UCL
- negative regulation of endothelial cell proliferation : IDA:BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway : TAS:BHF-UCL
- negative regulation of fibrinolysis : IDA:BHF-UCL
- negative regulation of fibroblast growth factor receptor signaling pathway : IDA:BHF-UCL
- negative regulation of focal adhesion assembly : TAS:BHF-UCL
- negative regulation of interleukin-12 production : IDA:BHF-UCL
- negative regulation of long-chain fatty acid import across plasma membrane : IDA:BHF-UCL
- negative regulation of nitric oxide mediated signal transduction : IDA:BHF-UCL
- negative regulation of plasminogen activation : IDA:BHF-UCL
- negative regulation of sprouting angiogenesis : IGI:BHF-UCL
- peptide cross-linking : IDA:BHF-UCL
- platelet degranulation : TAS:Reactome
- positive regulation of angiogenesis : IMP:BHF-UCL
- positive regulation of blood coagulation : IDA:BHF-UCL
- positive regulation of blood vessel endothelial cell migration : IDA:BHF-UCL
- positive regulation of cell migration : IDA:BHF-UCL
- positive regulation of cell population proliferation : IDA:BHF-UCL
- positive regulation of chemotaxis : IDA:BHF-UCL
- positive regulation of endothelial cell apoptotic process : IDA:UniProtKB
- positive regulation of endothelial cell migration : IDA:BHF-UCL
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors : IDA:BHF-UCL
- positive regulation of fibroblast migration : IDA:BHF-UCL
- positive regulation of macrophage activation : IDA:BHF-UCL
- positive regulation of macrophage chemotaxis : ISS:BHF-UCL
- positive regulation of phosphorylation : IMP:BHF-UCL
- positive regulation of protein kinase B signaling : IDA:UniProtKB
- positive regulation of reactive oxygen species metabolic process : IDA:BHF-UCL
- positive regulation of smooth muscle cell proliferation : IDA:BHF-UCL
- positive regulation of transforming growth factor beta receptor signaling pathway : IDA:BHF-UCL
- positive regulation of transforming growth factor beta1 production : ISS:BHF-UCL
- positive regulation of translation : IDA:BHF-UCL
- positive regulation of tumor necrosis factor biosynthetic process : IDA:UniProtKB
- regulation of megakaryocyte differentiation : TAS:Reactome
- response to calcium ion : IDA:BHF-UCL
- response to drug : IEP:UniProtKB
- response to endoplasmic reticulum stress : ISS:UniProtKB
- response to glucose : IDA:BHF-UCL
- response to hypoxia : NAS:BHF-UCL
- response to magnesium ion : IDA:BHF-UCL
- response to mechanical stimulus : IEA:Ensembl
- response to progesterone : TAS:BHF-UCL
- response to testosterone : IEA:Ensembl
- response to unfolded protein : IEA:UniProtKB-KW
- sprouting angiogenesis : IMP:BHF-UCL
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