Laminin subunit beta-1 (P07942)

Uniprot ID P07942
Protein Name Laminin subunit beta-1
Gene Name LAMB1
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.431
Function Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. .
GO - Molecular function
  • extracellular matrix structural constituent : IDA:HGNC
  • structural molecule activity : NAS:UniProtKB
GO - Biological process
  • cell adhesion : TAS:HGNC
  • cellular protein metabolic process : TAS:Reactome
  • endodermal cell differentiation : IEP:UniProtKB
  • extracellular matrix organization : TAS:Reactome
  • neuron projection development : IDA:UniProtKB
  • neuronal-glial interaction involved in cerebral cortex radial glia guided migration : IMP:UniProtKB
  • odontogenesis : IDA:UniProtKB
  • positive regulation of cell migration : IDA:UniProtKB
  • positive regulation of epithelial cell proliferation : TAS:HGNC
  • post-translational protein modification : TAS:Reactome
  • substrate adhesion-dependent cell spreading : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.