Heat shock protein HSP 90-alpha (P07901)

Uniprot ID P07901
Protein Name Heat shock protein HSP 90-alpha
Gene Name Hsp90aa1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.311
Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. .
GO - Molecular function
  • ATP binding : ISS:UniProtKB
  • ATPase activity : ISS:UniProtKB
  • CTP binding : ISO:MGI
  • dATP binding : ISO:MGI
  • disordered domain specific binding : ISO:MGI
  • DNA polymerase binding : ISO:MGI
  • GTP binding : ISO:MGI
  • GTPase binding : ISO:MGI
  • histone deacetylase binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • ion channel binding : ISO:MGI
  • mRNA binding : ISO:MGI
  • nitric-oxide synthase regulator activity : IDA:UniProtKB
  • protein homodimerization activity : IDA:MGI
  • protein kinase binding : ISO:MGI
  • protein phosphatase binding : ISO:MGI
  • protein tyrosine kinase activity : ISO:MGI
  • protein tyrosine kinase binding : ISO:MGI
  • Rho GDP-dissociation inhibitor binding : ISO:MGI
  • scaffold protein binding : ISO:MGI
  • sulfonylurea receptor binding : ISO:MGI
  • tau protein binding : ISO:MGI
  • TPR domain binding : ISS:UniProtKB
  • ubiquitin protein ligase binding : ISO:MGI
  • unfolded protein binding : TAS:UniProtKB
  • UTP binding : ISO:MGI
GO - Biological process
  • axon extension : IMP:ARUK-UCL
  • central nervous system neuron axonogenesis : IMP:ARUK-UCL
  • chaperone-mediated protein complex assembly : ISO:MGI
  • establishment of cell polarity : IMP:ARUK-UCL
  • neuron migration : ISO:MGI
  • nitric oxide biosynthetic process : TAS:UniProtKB
  • positive regulation of cell size : ISO:MGI
  • positive regulation of cellular protein catabolic process : ISO:MGI
  • positive regulation of cytotoxic T cell differentiation : TAS:UniProtKB
  • positive regulation of lamellipodium assembly : ISO:MGI
  • positive regulation of nitric oxide biosynthetic process : IDA:UniProtKB
  • positive regulation of peptidyl-serine phosphorylation : IMP:ARUK-UCL
  • positive regulation of protein import into nucleus, translocation : ISO:MGI
  • positive regulation of protein kinase B signaling : IMP:ARUK-UCL
  • positive regulation of protein phosphorylation : ISO:MGI
  • positive regulation of protein polymerization : ISO:MGI
  • positive regulation of tau-protein kinase activity : ISO:MGI
  • positive regulation of telomerase activity : ISO:MGI
  • protein import into mitochondrial outer membrane : ISO:MGI
  • protein refolding : TAS:UniProtKB
  • protein stabilization : ISO:MGI
  • regulation of cellular protein localization : IMP:ARUK-UCL
  • regulation of protein ubiquitination : ISO:MGI
  • response to antibiotic : ISS:AgBase
  • response to cold : ISS:AgBase
  • response to heat : ISS:AgBase
  • response to unfolded protein : TAS:UniProtKB
  • telomerase holoenzyme complex assembly : ISO:MGI
  • telomere maintenance via telomerase : ISO:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.