Superoxide dismutase [Mn], mitochondrial (P07895)

Uniprot ID P07895
Protein Name Superoxide dismutase [Mn], mitochondrial
Gene Name Sod2
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. .
GO - Molecular function
  • DNA binding : IDA:RGD
  • enzyme binding : IPI:RGD
  • identical protein binding : IPI:RGD
  • manganese ion binding : IDA:RGD
  • metal ion binding : IBA:GO_Central
  • oxidoreductase activity : ISO:RGD
  • oxygen binding : IDA:RGD
  • superoxide dismutase activity : IDA:RGD
GO - Biological process
  • acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure : ISO:RGD
  • age-dependent response to oxidative stress : ISO:RGD
  • age-dependent response to reactive oxygen species : ISS:UniProtKB
  • aging : IEP:RGD
  • apoptotic mitochondrial changes : ISO:RGD
  • cellular response to ethanol : IEP:RGD
  • detection of oxygen : ISO:RGD
  • erythrophore differentiation : ISO:RGD
  • glutathione metabolic process : ISO:RGD
  • heart development : ISO:RGD
  • hemopoiesis : ISO:RGD
  • hydrogen peroxide biosynthetic process : IDA:RGD
  • hydrogen peroxide metabolic process : IMP:RGD
  • intrinsic apoptotic signaling pathway in response to DNA damage : ISO:RGD
  • intrinsic apoptotic signaling pathway in response to oxidative stress : ISO:RGD
  • iron ion homeostasis : ISO:RGD
  • liver development : ISO:RGD
  • locomotory behavior : ISO:RGD
  • mitochondrion organization : ISO:RGD
  • negative regulation of apoptotic process : IMP:RGD
  • negative regulation of cell population proliferation : ISO:RGD
  • negative regulation of fat cell differentiation : ISO:RGD
  • negative regulation of fibroblast proliferation : ISO:RGD
  • negative regulation of neuron apoptotic process : ISO:RGD
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway : ISO:RGD
  • negative regulation of vascular smooth muscle cell proliferation : ISO:RGD
  • neuron development : ISO:RGD
  • oxygen homeostasis : ISO:RGD
  • positive regulation of cell migration : ISO:RGD
  • positive regulation of nitric oxide biosynthetic process : ISO:RGD
  • positive regulation of vascular associated smooth muscle cell apoptotic process : ISO:RGD
  • positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching : ISO:RGD
  • post-embryonic development : ISO:RGD
  • protein homotetramerization : ISO:RGD
  • regulation of blood pressure : ISO:RGD
  • regulation of catalytic activity : ISO:RGD
  • regulation of mitochondrial membrane potential : ISO:RGD
  • regulation of transcription by RNA polymerase II : ISS:UniProtKB
  • release of cytochrome c from mitochondria : ISO:RGD
  • removal of superoxide radicals : IDA:RGD
  • respiratory electron transport chain : ISO:RGD
  • response to activity : IEP:RGD
  • response to axon injury : ISO:RGD
  • response to cadmium ion : IEP:RGD
  • response to cold : IEP:RGD
  • response to drug : IDA:RGD
  • response to electrical stimulus : IEP:RGD
  • response to gamma radiation : ISO:RGD
  • response to hydrogen peroxide : IEP:RGD
  • response to hyperoxia : ISO:RGD
  • response to hypoxia : IEP:RGD
  • response to immobilization stress : IEP:RGD
  • response to isolation stress : IEP:RGD
  • response to L-ascorbic acid : IEP:RGD
  • response to lipopolysaccharide : IEP:RGD
  • response to magnetism : IEP:RGD
  • response to manganese ion : IEP:RGD
  • response to nutrient levels : IDA:RGD
  • response to oxidative stress : IEP:RGD
  • response to radiation : IEP:RGD
  • response to reactive oxygen species : ISO:RGD
  • response to selenium ion : IEP:RGD
  • response to silicon dioxide : IEP:RGD
  • response to superoxide : ISO:RGD
  • response to zinc ion : IEP:RGD
  • superoxide anion generation : ISO:RGD
  • superoxide metabolic process : ISS:UniProtKB
  • vasodilation : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.