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P07742

Ribonucleoside-diphosphate reductase large subunit (P07742)

Uniprot ID P07742
Protein Name Ribonucleoside-diphosphate reductase large subunit
Gene Name Rrm1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.45
Function Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • disordered domain specific binding : IPI:CAFA
  • identical protein binding : ISO:MGI
  • purine nucleotide binding : IDA:MGI
  • ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor : IDA:UniProtKB
GO - Biological process
  • cell proliferation in forebrain : IEA:Ensembl
  • deoxyribonucleotide biosynthetic process : IDA:UniProtKB
  • DNA replication : IEA:UniProtKB-UniPathway
  • male gonad development : IEA:Ensembl
  • mitotic cell cycle : IEA:Ensembl
  • protein complex oligomerization : IPI:MGI
  • protein heterotetramerization : IDA:CAFA
  • pyrimidine nucleobase metabolic process : IEA:Ensembl
  • response to ionizing radiation : IEA:Ensembl
  • retina development in camera-type eye : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.