Beta-hexosaminidase subunit beta (P07686)

Uniprot ID P07686
Protein Name Beta-hexosaminidase subunit beta
Gene Name HEXB
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.693
Function Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
GO - Molecular function
  • acetylglucosaminyltransferase activity : IDA:UniProtKB
  • beta-N-acetylhexosaminidase activity : TAS:ProtInc
  • N-acetyl-beta-D-galactosaminidase activity : IEA:UniProtKB-EC
  • protein heterodimerization activity : IDA:MGI
  • protein homodimerization activity : IDA:MGI
GO - Biological process
  • astrocyte cell migration : IEA:Ensembl
  • cellular calcium ion homeostasis : IEA:Ensembl
  • cellular protein metabolic process : IEA:Ensembl
  • chondroitin sulfate catabolic process : TAS:Reactome
  • ganglioside catabolic process : IEA:Ensembl
  • glycosphingolipid metabolic process : TAS:Reactome
  • hyaluronan catabolic process : TAS:Reactome
  • keratan sulfate catabolic process : TAS:Reactome
  • lipid storage : IEA:Ensembl
  • locomotory behavior : IEA:Ensembl
  • lysosome organization : IEA:Ensembl
  • male courtship behavior : IEA:Ensembl
  • myelination : IEA:Ensembl
  • neuromuscular process controlling balance : IEA:Ensembl
  • neutrophil degranulation : TAS:Reactome
  • oligosaccharide catabolic process : IEA:Ensembl
  • oogenesis : IEA:Ensembl
  • penetration of zona pellucida : IEA:Ensembl
  • phospholipid biosynthetic process : IEA:Ensembl
  • positive regulation of transcription by RNA polymerase II : IEA:Ensembl
  • regulation of cell shape : IEA:Ensembl
  • sensory perception of sound : IEA:Ensembl
  • skeletal system development : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.