| Signal peptide(a) |
N |
Secretome P(b) |
0.824 |
| Function |
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:22848640). . |
| GO - Molecular function |
- bone sialoprotein binding : ISO:MGI
- cadherin binding involved in cell-cell adhesion : ISO:MGI
- calcium ion binding : IEA:InterPro
- calcium-dependent phospholipid binding : ISO:MGI
- calcium-dependent protein binding : ISO:MGI
- cytoskeletal protein binding : IEA:InterPro
- identical protein binding : ISO:MGI
- molecular function regulator : ISO:MGI
- phosphatidylinositol-4,5-bisphosphate binding : ISO:MGI
- phospholipase A2 inhibitor activity : ISO:MGI
- protease binding : ISO:MGI
- Rab GTPase binding : ISO:MGI
- S100 protein binding : ISO:MGI
|
| GO - Biological process |
- angiogenesis : IMP:MGI
- body fluid secretion : ISO:MGI
- catabolism by host of symbiont protein : ISO:MGI
- collagen fibril organization : IMP:MGI
- fibrinolysis : IMP:MGI
- membrane raft assembly : ISO:MGI
- negative regulation by host of symbiont molecular function : ISO:MGI
- negative regulation of development of symbiont involved in interaction with host : ISO:MGI
- negative regulation of low-density lipoprotein particle receptor catabolic process : IMP:BHF-UCL
- osteoclast development : ISO:MGI
- positive regulation of binding : IMP:MGI
- positive regulation of fibroblast proliferation : ISO:MGI
- positive regulation of low-density lipoprotein particle clearance : IMP:BHF-UCL
- positive regulation of low-density lipoprotein particle receptor binding : IMP:BHF-UCL
- positive regulation of low-density lipoprotein receptor activity : IMP:BHF-UCL
- positive regulation of protein phosphorylation : ISO:MGI
- positive regulation of receptor recycling : IMP:BHF-UCL
- positive regulation of receptor-mediated endocytosis involved in cholesterol transport : IMP:BHF-UCL
- positive regulation of vacuole organization : ISO:MGI
- positive regulation of vesicle fusion : ISO:MGI
- protein heterotetramerization : ISO:MGI
- protein localization to plasma membrane : ISO:MGI
- response to thyroid hormone : IEA:Ensembl
- vesicle budding from membrane : ISO:MGI
|