Gamma-enolase (P07323)

Uniprot ID P07323
Protein Name Gamma-enolase
Gene Name Eno2
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.
GO - Molecular function
  • enzyme binding : IPI:CAFA
  • identical protein binding : IPI:RGD
  • magnesium ion binding : IEA:InterPro
  • phosphopyruvate hydratase activity : IDA:CAFA
  • protein-containing complex binding : IDA:RGD
GO - Biological process
  • canonical glycolysis : IDA:CAFA
  • gluconeogenesis : IDA:RGD
  • glycolytic process : IDA:RGD
  • multicellular organismal reproductive process : IEP:RGD
  • negative regulation of neuron death : IMP:CAFA
  • regulation of neuron death : IGI:CAFA
  • response to drug : IEP:RGD
  • response to estradiol : IEP:RGD
  • response to organic cyclic compound : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.