Tumor necrosis factor receptor superfamily member 16 (P07174)

Uniprot ID P07174
Protein Name Tumor necrosis factor receptor superfamily member 16
Gene Name Ngfr
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4 (PubMed:3027580, PubMed:15131306, PubMed:18596692). Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487, PubMed:22155786). In response to proNGF binding, the heterodimeric receptor with SORCS2 activates a signaling cascade that leads to decreased Rac activity, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells (PubMed:10514511, PubMed:10985348, PubMed:24908487). Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (By similarity). .
GO - Molecular function
  • amyloid-beta binding : IPI:RGD
  • calmodulin binding : ISS:UniProtKB
  • coreceptor activity : ISO:RGD
  • death receptor activity : ISO:RGD
  • identical protein binding : IPI:IntAct
  • nerve growth factor binding : IDA:RGD
  • neurotrophin binding : IPI:RGD
  • neurotrophin TRKA receptor binding : IPI:RGD
  • preprotein binding : IPI:RGD
  • protein-containing complex binding : IPI:RGD
  • Rab GTPase binding : ISS:UniProtKB
  • ubiquitin protein ligase binding : ISO:RGD
GO - Biological process
  • activation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:RGD
  • axon guidance : ISO:RGD
  • cellular glucose homeostasis : ISS:UniProtKB
  • cellular response to amyloid-beta : ISO:RGD
  • cellular response to oxidative stress : IMP:RGD
  • central nervous system development : ISO:RGD
  • circadian regulation of gene expression : ISS:UniProtKB
  • circadian rhythm : ISO:RGD
  • detection of temperature stimulus : ISO:RGD
  • dorsal aorta development : ISO:RGD
  • glucose homeostasis : ISS:UniProtKB
  • hair follicle morphogenesis : ISO:RGD
  • intracellular protein transport : ISS:UniProtKB
  • negative regulation of angiogenesis : IMP:RGD
  • negative regulation of apoptotic process : IMP:RGD
  • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis : ISO:RGD
  • negative regulation of dendritic spine development : IMP:RGD
  • negative regulation of fibroblast growth factor receptor signaling pathway : ISO:RGD
  • negative regulation of hair follicle development : ISO:RGD
  • negative regulation of mitochondrial depolarization : IMP:RGD
  • negative regulation of neuron apoptotic process : IMP:RGD
  • negative regulation of neuron projection development : IDA:RGD
  • nerve development : ISO:RGD
  • neuron apoptotic process : ISO:RGD
  • positive regulation of apoptotic process : IMP:RGD
  • positive regulation of apoptotic signaling pathway : ISO:RGD
  • positive regulation of excitatory postsynaptic potential : IMP:RGD
  • positive regulation of fibroblast proliferation : ISO:RGD
  • positive regulation of MAPK cascade : IDA:RGD
  • positive regulation of myelination : IMP:RGD
  • positive regulation of neural precursor cell proliferation : IMP:RGD
  • positive regulation of neuron death : IDA:RGD
  • positive regulation of neuron differentiation : IDA:RGD
  • positive regulation of neuron projection development : IMP:RGD
  • positive regulation of odontogenesis of dentin-containing tooth : ISO:RGD
  • positive regulation of pri-miRNA transcription by RNA polymerase II : ISO:RGD
  • positive regulation of protein kinase B signaling : IDA:RGD
  • positive regulation of protein localization to nucleus : ISO:RGD
  • positive regulation of Rho protein signal transduction : IDA:RGD
  • positive regulation of synaptic transmission, cholinergic : IMP:RGD
  • positive regulation of synaptic transmission, glutamatergic : IMP:RGD
  • regulation of cell death : IDA:RGD
  • regulation of gene expression : ISO:RGD
  • regulation of reactive oxygen species metabolic process : IMP:RGD
  • response to lipopolysaccharide : IEP:RGD
  • response to wounding : IMP:RGD
  • Rho protein signal transduction : ISO:RGD
  • sensory perception of pain : IMP:RGD
  • signal transduction : IDA:RGD
  • skeletal muscle cell differentiation : IEP:RGD
  • skin development : ISO:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.