| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). .[Procathepsin L]: Procathepsin L is required for maximal stimulation of steroidogenesis by TIMP1. {ECO:0000269|PubMed:7777858}. |
| GO - Molecular function |
- aminopeptidase activity : IDA:RGD
- collagen binding : ISO:RGD
- cysteine-type carboxypeptidase activity : ISO:RGD
- cysteine-type endopeptidase activity : IDA:CAFA
- cysteine-type peptidase activity : ISO:RGD
- endopeptidase activity : ISO:RGD
- fibronectin binding : ISO:RGD
- histone binding : ISO:RGD
- kininogen binding : IPI:RGD
- peptide binding : IDA:RGD
- protein-containing complex binding : IPI:RGD
- proteoglycan binding : ISO:RGD
- serpin family protein binding : ISO:RGD
|
| GO - Biological process |
- adaptive immune response : ISO:RGD
- autophagic cell death : IEP:RGD
- cell communication : IDA:RGD
- cellular response to starvation : IEP:RGD
- cellular response to thyroid hormone stimulus : ISO:RGD
- collagen catabolic process : ISO:RGD
- decidualization : IEP:RGD
- hair follicle morphogenesis : ISO:RGD
- male gonad development : IEP:RGD
- multicellular organism aging : IEP:RGD
- negative regulation of keratinocyte proliferation : ISO:RGD
- nerve development : IEP:RGD
- protein autoprocessing : ISO:RGD
- protein processing : ISO:RGD
- proteolysis : IDA:CAFA
- proteolysis involved in cellular protein catabolic process : ISO:RGD
- regulation of actin cytoskeleton reorganization : ISO:RGD
- response to glucocorticoid : IEP:RGD
- response to glucose : IEP:RGD
- response to gonadotropin : IEP:RGD
- response to odorant : IEP:RGD
- response to organic cyclic compound : IEP:RGD
- Sertoli cell differentiation : IEP:RGD
- spermatogenesis : IEP:RGD
|