Beta-2-microglobulin (P07151)

Uniprot ID P07151
Protein Name Beta-2-microglobulin
Gene Name B2m
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
GO - Molecular function
  • identical protein binding : ISO:RGD
  • protein homodimerization activity : ISO:RGD
GO - Biological process
  • amyloid fibril formation : ISO:RGD
  • antibacterial humoral response : ISO:RGD
  • antigen processing and presentation of endogenous peptide antigen via MHC class I : ISO:RGD
  • antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent : ISO:RGD
  • antimicrobial humoral immune response mediated by antimicrobial peptide : ISO:RGD
  • cellular response to iron ion : ISO:RGD
  • cellular response to iron(III) ion : ISO:RGD
  • cellular response to lipopolysaccharide : ISO:RGD
  • cellular response to nicotine : ISO:RGD
  • defense response to Gram-negative bacterium : ISO:RGD
  • defense response to Gram-positive bacterium : ISO:RGD
  • innate immune response : ISO:RGD
  • iron ion homeostasis : ISO:RGD
  • iron ion transport : ISO:RGD
  • learning or memory : ISO:RGD
  • modulation of age-related behavioral decline : ISO:RGD
  • multicellular organism development : ISO:RGD
  • negative regulation of epithelial cell proliferation : ISO:RGD
  • negative regulation of forebrain neuron differentiation : ISO:RGD
  • negative regulation of neurogenesis : ISO:RGD
  • negative regulation of neuron projection development : ISO:RGD
  • negative regulation of receptor binding : ISO:RGD
  • positive regulation of cellular senescence : ISO:RGD
  • positive regulation of ferrous iron binding : ISO:RGD
  • positive regulation of protein binding : ISO:RGD
  • positive regulation of receptor binding : ISO:RGD
  • positive regulation of receptor-mediated endocytosis : ISO:RGD
  • positive regulation of T cell cytokine production : ISO:RGD
  • positive regulation of T cell mediated cytotoxicity : ISO:RGD
  • positive regulation of transferrin receptor binding : ISO:RGD
  • protein homotetramerization : ISO:RGD
  • protein refolding : ISO:RGD
  • regulation of erythrocyte differentiation : ISO:RGD
  • regulation of iron ion transport : ISO:RGD
  • regulation of membrane depolarization : ISO:RGD
  • response to cadmium ion : IEP:RGD
  • response to drug : IEP:RGD
  • response to molecule of bacterial origin : ISO:RGD
  • T cell differentiation in thymus : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.