Glia-derived nexin (P07093)

Uniprot ID P07093
Protein Name Glia-derived nexin
Gene Name SERPINE2
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.61
Function Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
GO - Molecular function
  • glycosaminoglycan binding : IDA:BHF-UCL
  • heparin binding : IDA:BHF-UCL
  • serine-type endopeptidase inhibitor activity : IDA:BHF-UCL
  • signaling receptor binding : IPI:BHF-UCL
GO - Biological process
  • blood coagulation : TAS:Reactome
  • cerebellar granular layer morphogenesis : IEA:Ensembl
  • detection of mechanical stimulus involved in sensory perception : IEA:Ensembl
  • innervation : IEA:Ensembl
  • long-term synaptic potentiation : IEA:Ensembl
  • mating plug formation : IEA:Ensembl
  • negative regulation of blood coagulation : IDA:BHF-UCL
  • negative regulation of cell growth : IEA:Ensembl
  • negative regulation of cell population proliferation : IEA:Ensembl
  • negative regulation of endopeptidase activity : IBA:GO_Central
  • negative regulation of phosphatidylinositol 3-kinase signaling : IEA:Ensembl
  • negative regulation of plasminogen activation : IMP:BHF-UCL
  • negative regulation of platelet aggregation : ISS:BHF-UCL
  • negative regulation of protein catabolic process : IEA:Ensembl
  • negative regulation of protein processing : IC:BHF-UCL
  • negative regulation of proteolysis : IDA:BHF-UCL
  • negative regulation of smoothened signaling pathway : IEA:Ensembl
  • negative regulation of sodium ion transport : IEA:Ensembl
  • positive regulation of astrocyte differentiation : IDA:BHF-UCL
  • regulation of cell migration : NAS:UniProtKB
  • regulation of synaptic transmission, glutamatergic : IEA:Ensembl
  • regulation of timing of cell differentiation : IEA:Ensembl
  • secretion by cell : IEA:Ensembl
  • secretory granule organization : IEA:Ensembl
  • seminal vesicle epithelium development : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.