Glia-derived nexin (P07092)

Uniprot ID P07092
Protein Name Glia-derived nexin
Gene Name Serpine2
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b) 0.0
Function Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. .
GO - Molecular function
  • glycosaminoglycan binding : ISO:RGD
  • heparin binding : IDA:RGD
  • serine-type endopeptidase inhibitor activity : IDA:RGD
  • signaling receptor binding : ISO:RGD
GO - Biological process
  • blood coagulation : ISO:RGD
  • cerebellar granular layer morphogenesis : ISO:RGD
  • dense core granule biogenesis : IDA:RGD
  • detection of mechanical stimulus involved in sensory perception : ISO:RGD
  • embryo implantation : IEP:RGD
  • innervation : ISO:RGD
  • long-term synaptic potentiation : ISO:RGD
  • mating plug formation : ISO:RGD
  • negative regulation of blood coagulation : IDA:BHF-UCL
  • negative regulation of cell growth : ISO:RGD
  • negative regulation of cell population proliferation : ISO:RGD
  • negative regulation of endopeptidase activity : IBA:GO_Central
  • negative regulation of peptidase activity : ISO:RGD
  • negative regulation of phosphatidylinositol 3-kinase signaling : ISO:RGD
  • negative regulation of plasminogen activation : ISO:RGD
  • negative regulation of platelet activation : ISO:RGD
  • negative regulation of platelet aggregation : ISO:RGD
  • negative regulation of protein catabolic process : ISO:RGD
  • negative regulation of proteolysis : IDA:BHF-UCL
  • negative regulation of smoothened signaling pathway : ISO:RGD
  • negative regulation of sodium ion transport : ISO:RGD
  • positive regulation of astrocyte differentiation : ISO:RGD
  • positive regulation of neuron projection development : IDA:RGD
  • regulation of synaptic transmission, glutamatergic : ISO:RGD
  • regulation of timing of cell differentiation : ISO:RGD
  • response to radiation : IEP:RGD
  • response to wounding : ISO:RGD
  • secretion by cell : ISO:RGD
  • secretory granule organization : IDA:RGD
  • seminal vesicle epithelium development : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.