Complement factor H (P06909)

Uniprot ID P06909
Protein Name Complement factor H
Gene Name Cfh
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.438
Function Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. .
GO - Molecular function
  • complement component C3b binding : IPI:MGI
  • heparan sulfate proteoglycan binding : ISO:MGI
  • heparin binding : IDA:MGI
GO - Biological process
  • complement activation : ISO:MGI
  • complement activation, alternative pathway : IEA:UniProtKB-KW
  • positive regulation of cytolysis : IDA:UniProtKB
  • regulation of complement activation : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.