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P06869

Urokinase-type plasminogen activator (P06869)

Uniprot ID P06869
Protein Name Urokinase-type plasminogen activator
Gene Name Plau
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (20) Interactions
Signal peptide(a) Y Secretome P(b) 0.571
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
GO - Molecular function
  • peptidase activity : ISO:MGI
  • serine-type endopeptidase activity : IBA:GO_Central
GO - Biological process
  • angiogenesis : ISO:MGI
  • fibrinolysis : IMP:MGI
  • neuron death : ISO:MGI
  • plasminogen activation : ISO:MGI
  • positive regulation of cell migration : ISO:MGI
  • positive regulation of cell proliferation : ISO:MGI
  • positive regulation of ovulation : ISO:MGI
  • positive regulation of reactive oxygen species metabolic process : ISO:MGI
  • positive regulation of smooth muscle cell migration : ISO:MGI
  • proteolysis : IBA:GO_Central
  • regulation of cell adhesion mediated by integrin : ISO:MGI
  • regulation of cell proliferation : IGI:MGI
  • regulation of hepatocyte proliferation : ISO:MGI
  • regulation of signaling receptor activity : ISO:MGI
  • regulation of smooth muscle cell migration : ISO:MGI
  • regulation of smooth muscle cell-matrix adhesion : ISO:MGI
  • response to hypoxia : IMP:MGI
  • skeletal muscle tissue regeneration : ISO:MGI
  • smooth muscle cell migration : IMP:MGI
  • wound healing : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.