Beta-hexosaminidase subunit alpha (P06865)

Uniprot ID P06865
Protein Name Beta-hexosaminidase subunit alpha
Gene Name HEXA
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.74
Function Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.
GO - Molecular function
  • acetylglucosaminyltransferase activity : IDA:UniProtKB
  • beta-N-acetylhexosaminidase activity : TAS:Reactome
  • N-acetyl-beta-D-galactosaminidase activity : IEA:UniProtKB-EC
  • protein heterodimerization activity : IDA:MGI
GO - Biological process
  • carbohydrate metabolic process : IEA:InterPro
  • chondroitin sulfate catabolic process : TAS:Reactome
  • glycosaminoglycan biosynthetic process : IDA:UniProtKB
  • glycosphingolipid metabolic process : TAS:Reactome
  • hyaluronan catabolic process : TAS:Reactome
  • keratan sulfate catabolic process : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.