Tumor necrosis factor (P06804)

Uniprot ID P06804
Protein Name Tumor necrosis factor
Gene Name Tnf
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.928
Function Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. .
GO - Molecular function
  • cytokine activity : IDA:MGI
  • identical protein binding : ISO:MGI
  • protease binding : IPI:BHF-UCL
  • transcription regulatory region DNA binding : ISO:MGI
  • tumor necrosis factor receptor binding : IDA:MGI
GO - Biological process
  • activation of cysteine-type endopeptidase activity involved in apoptotic process : IDA:MGI
  • activation of MAPK activity : ISO:MGI
  • activation of MAPKKK activity : ISO:MGI
  • animal organ morphogenesis : IMP:MGI
  • apoptotic process : ISO:MGI
  • apoptotic signaling pathway : IDA:MGI
  • calcium-mediated signaling : ISO:MGI
  • cell activation : ISO:MGI
  • cell proliferation : TAS:MGI
  • cellular extravasation : IDA:MGI
  • cellular response to amino acid stimulus : IDA:MGI
  • cellular response to lipopolysaccharide : IDA:MGI
  • cellular response to nicotine : ISO:MGI
  • cellular response to organic cyclic compound : ISO:MGI
  • chronic inflammatory response to antigenic stimulus : ISO:MGI
  • cortical actin cytoskeleton organization : ISO:MGI
  • defense response : IMP:MGI
  • defense response to bacterium : IDA:MGI
  • defense response to Gram-positive bacterium : IGI:MGI
  • detection of mechanical stimulus involved in sensory perception of pain : ISO:MGI
  • embryonic digestive tract development : IEA:Ensembl
  • endothelial cell apoptotic process : IDA:BHF-UCL
  • epithelial cell proliferation involved in salivary gland morphogenesis : IDA:MGI
  • extracellular matrix organization : IDA:MGI
  • extrinsic apoptotic signaling pathway : IGI:MGI
  • extrinsic apoptotic signaling pathway via death domain receptors : IGI:MGI
  • glucose metabolic process : IDA:MGI
  • humoral immune response : IMP:MGI
  • inflammatory response : IGI:MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage : IDA:MGI
  • JNK cascade : IGI:MGI
  • leukocyte migration : IDA:MGI
  • leukocyte tethering or rolling : ISO:MGI
  • lipopolysaccharide-mediated signaling pathway : ISO:MGI
  • MAPK cascade : ISO:MGI
  • multicellular organism development : IMP:MGI
  • necroptotic signaling pathway : IGI:MGI
  • negative regulation of alkaline phosphatase activity : IDA:BHF-UCL
  • negative regulation of bicellular tight junction assembly : ISO:MGI
  • negative regulation of branching involved in lung morphogenesis : ISO:MGI
  • negative regulation of cell proliferation : ISO:MGI
  • negative regulation of cytokine secretion involved in immune response : ISO:MGI
  • negative regulation of endothelial cell proliferation : IDA:BHF-UCL
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:MGI
  • negative regulation of gene expression : IDA:MGI
  • negative regulation of glucose import : IDA:MGI
  • negative regulation of growth of symbiont in host : IGI:MGI
  • negative regulation of interleukin-6 production : ISO:MGI
  • negative regulation of L-glutamate import across plasma membrane : ISO:MGI
  • negative regulation of lipid catabolic process : ISO:MGI
  • negative regulation of mitotic cell cycle : IDA:BHF-UCL
  • negative regulation of myelination : ISO:MGI
  • negative regulation of myoblast differentiation : IMP:MGI
  • negative regulation of myosin-light-chain-phosphatase activity : ISO:MGI
  • negative regulation of osteoblast differentiation : IDA:BHF-UCL
  • negative regulation of protein complex disassembly : ISS:UniProtKB
  • negative regulation of transcription by RNA polymerase II : IDA:BHF-UCL
  • negative regulation of transcription, DNA-templated : ISO:MGI
  • negative regulation of viral genome replication : ISO:MGI
  • osteoclast differentiation : IGI:MGI
  • positive regulation of action potential : ISO:MGI
  • positive regulation of apoptotic process : ISS:UniProtKB
  • positive regulation of blood microparticle formation : ISO:MGI
  • positive regulation of calcidiol 1-monooxygenase activity : ISO:MGI
  • positive regulation of calcineurin-NFAT signaling cascade : ISO:MGI
  • positive regulation of cell adhesion : ISO:MGI
  • positive regulation of cell proliferation : TAS:MGI
  • positive regulation of chemokine (C-X-C motif) ligand 2 production : ISO:MGI
  • positive regulation of chemokine biosynthetic process : ISO:MGI
  • positive regulation of chemokine production : ISO:MGI
  • positive regulation of chronic inflammatory response to antigenic stimulus : IGI:MGI
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:MGI
  • positive regulation of cytokine production : ISO:MGI
  • positive regulation of cytokine secretion : ISO:MGI
  • positive regulation of DNA binding transcription factor activity : ISO:MGI
  • positive regulation of fever generation : IDA:BHF-UCL
  • positive regulation of gene expression : ISO:MGI
  • positive regulation of hair follicle development : IMP:UniProtKB
  • positive regulation of heterotypic cell-cell adhesion : IDA:BHF-UCL
  • positive regulation of humoral immune response mediated by circulating immunoglobulin : IGI:MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling : IDA:MGI
  • positive regulation of inflammatory response : ISO:MGI
  • positive regulation of interferon-gamma production : IGI:MGI
  • positive regulation of interleukin-18 production : ISO:MGI
  • positive regulation of interleukin-6 production : IDA:MGI
  • positive regulation of interleukin-8 biosynthetic process : ISO:MGI
  • positive regulation of interleukin-8 production : ISO:MGI
  • positive regulation of JNK cascade : IDA:MGI
  • positive regulation of JUN kinase activity : ISS:UniProtKB
  • positive regulation of leukocyte adhesion to arterial endothelial cell : ISO:MGI
  • positive regulation of leukocyte adhesion to vascular endothelial cell : ISO:MGI
  • positive regulation of MAP kinase activity : ISS:UniProtKB
  • positive regulation of membrane protein ectodomain proteolysis : ISO:MGI
  • positive regulation of mitotic nuclear division : ISO:MGI
  • positive regulation of neuron apoptotic process : ISO:MGI
  • positive regulation of NF-kappaB transcription factor activity : ISS:UniProtKB
  • positive regulation of NIK/NF-kappaB signaling : IMP:BHF-UCL
  • positive regulation of nitric oxide biosynthetic process : ISO:MGI
  • positive regulation of osteoclast differentiation : ISO:MGI
  • positive regulation of peptidyl-serine phosphorylation : ISO:MGI
  • positive regulation of phagocytosis : ISO:MGI
  • positive regulation of podosome assembly : ISO:MGI
  • positive regulation of programmed cell death : ISO:MGI
  • positive regulation of protein catabolic process : ISO:MGI
  • positive regulation of protein complex assembly : ISO:MGI
  • positive regulation of protein complex disassembly : ISS:UniProtKB
  • positive regulation of protein kinase activity : ISO:MGI
  • positive regulation of protein kinase B signaling : IDA:MGI
  • positive regulation of protein localization to cell surface : ISO:MGI
  • positive regulation of protein phosphorylation : ISS:UniProtKB
  • positive regulation of protein transport : ISO:MGI
  • positive regulation of smooth muscle cell proliferation : ISO:MGI
  • positive regulation of superoxide dismutase activity : ISO:MGI
  • positive regulation of synaptic transmission : ISO:MGI
  • positive regulation of transcription by RNA polymerase II : IDA:MGI
  • positive regulation of transcription, DNA-templated : IDA:MGI
  • positive regulation of translational initiation by iron : IDA:MGI
  • positive regulation of vascular smooth muscle cell proliferation : IDA:BHF-UCL
  • positive regulation of vitamin D biosynthetic process : ISO:MGI
  • protein import into nucleus, translocation : ISO:MGI
  • protein kinase B signaling : ISO:MGI
  • protein localization to plasma membrane : ISO:MGI
  • receptor biosynthetic process : ISO:MGI
  • regulation of branching involved in salivary gland morphogenesis : IDA:MGI
  • regulation of cell proliferation : IDA:MGI
  • regulation of establishment of endothelial barrier : ISO:MGI
  • regulation of I-kappaB kinase/NF-kappaB signaling : ISO:MGI
  • regulation of immunoglobulin secretion : IDA:MGI
  • regulation of inflammatory response : IDA:MGI
  • regulation of insulin secretion : ISO:MGI
  • regulation of osteoclast differentiation : IDA:MGI
  • regulation of protein phosphorylation : IDA:MGI
  • regulation of protein secretion : IDA:MGI
  • regulation of reactive oxygen species metabolic process : IDA:MGI
  • response to glucocorticoid : ISO:MGI
  • response to lipopolysaccharide : ISO:MGI
  • response to organic substance : IDA:MGI
  • response to virus : ISO:MGI
  • sequestering of triglyceride : ISO:MGI
  • signal transduction : ISO:MGI
  • toll-like receptor 3 signaling pathway : ISO:MGI
  • tumor necrosis factor-mediated signaling pathway : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.