| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. . |
| GO - Molecular function |
- heparan sulfate proteoglycan binding : IDA:MGI
- heparin binding : IDA:MGI
- identical protein binding : ISO:MGI
- protein kinase binding : IPI:UniProtKB
- protein tyrosine phosphatase activity : IDA:MGI
|
| GO - Biological process |
- activation of MAPK activity : IMP:MGI
- B cell differentiation : IMP:MGI
- B cell proliferation : IMP:UniProtKB
- B cell receptor signaling pathway : IMP:UniProtKB
- bone marrow development : ISO:MGI
- cell cycle phase transition : ISO:MGI
- defense response to virus : IDA:MGI
- dephosphorylation : IDA:UniProtKB
- hematopoietic progenitor cell differentiation : ISO:MGI
- heterotypic cell-cell adhesion : IMP:MGI
- immunoglobulin biosynthetic process : ISO:MGI
- leukocyte cell-cell adhesion : IMP:MGI
- negative regulation of cell adhesion involved in substrate-bound cell migration : ISO:MGI
- negative regulation of cytokine-mediated signaling pathway : IDA:UniProtKB
- negative regulation of peptidyl-tyrosine phosphorylation : IMP:MGI
- negative regulation of protein autophosphorylation : IMP:MGI
- negative regulation of protein kinase activity : IDA:UniProtKB
- negative regulation of T cell mediated cytotoxicity : IMP:UniProtKB
- negative thymic T cell selection : IMP:MGI
- positive regulation of alpha-beta T cell proliferation : IMP:MGI
- positive regulation of antigen receptor-mediated signaling pathway : IMP:UniProtKB
- positive regulation of B cell proliferation : IMP:MGI
- positive regulation of extrinsic apoptotic signaling pathway : IMP:MGI
- positive regulation of gamma-delta T cell differentiation : IMP:MGI
- positive regulation of hematopoietic stem cell migration : ISO:MGI
- positive regulation of humoral immune response mediated by circulating immunoglobulin : IMP:MGI
- positive regulation of isotype switching to IgG isotypes : IMP:MGI
- positive regulation of MAPK cascade : IMP:MGI
- positive regulation of stem cell proliferation : ISO:MGI
- positive regulation of T cell differentiation : IMP:MGI
- positive regulation of T cell mediated cytotoxicity : IMP:MGI
- positive regulation of T cell mediated immunity : IMP:MGI
- positive regulation of T cell proliferation : IMP:UniProtKB
- positive thymic T cell selection : IMP:MGI
- protein dephosphorylation : IDA:UniProtKB
- regulation of B cell differentiation : IMP:MGI
- regulation of B cell receptor signaling pathway : IMP:MGI
- regulation of cell cycle : IDA:UniProtKB
- regulation of extrinsic apoptotic signaling pathway : IMP:MGI
- regulation of humoral immune response mediated by circulating immunoglobulin : IMP:MGI
- release of sequestered calcium ion into cytosol : IDA:UniProtKB
- response to gamma radiation : ISO:MGI
- stem cell development : ISO:MGI
- T cell differentiation : IMP:UniProtKB
- T cell proliferation : IMP:MGI
- T cell receptor signaling pathway : ISS:UniProtKB
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