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P06730

Eukaryotic translation initiation factor 4E (P06730)

Uniprot ID P06730
Protein Name Eukaryotic translation initiation factor 4E
Gene Name EIF4E
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.889
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. .
GO - Molecular function
  • enzyme binding : IDA:AgBase
  • eukaryotic initiation factor 4G binding : IDA:AgBase
  • repressing transcription factor binding : IDA:AgBase
  • RNA 7-methylguanosine cap binding : IDA:UniProtKB
  • RNA binding : HDA:UniProtKB
  • RNA cap binding : TAS:ProtInc
  • translation initiation factor activity : IDA:UniProtKB
GO - Biological process
  • G1/S transition of mitotic cell cycle : IMP:UniProtKB
  • mRNA export from nucleus : TAS:Reactome
  • positive regulation of mitotic cell cycle : IMP:UniProtKB
  • regulation of translation : IDA:UniProtKB
  • RNA export from nucleus : TAS:Reactome
  • translational initiation : TAS:Reactome
  • viral process : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.