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P05997

Collagen alpha-2(V) chain (P05997)

Uniprot ID P05997
Protein Name Collagen alpha-2(V) chain
Gene Name COL5A2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.087
Function Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). .
GO - Molecular function
  • extracellular matrix structural constituent : IEA:InterPro
  • metal ion binding : IEA:UniProtKB-KW
  • SMAD binding : IEA:Ensembl
GO - Biological process
  • cellular response to amino acid stimulus : IEA:Ensembl
  • collagen fibril organization : IMP:UniProtKB
  • extracellular matrix organization : TAS:Reactome
  • eye morphogenesis : IMP:UniProtKB
  • negative regulation of endodermal cell differentiation : IDA:UniProtKB
  • ossification : IEA:Ensembl
  • skeletal system development : IEA:Ensembl
  • skin development : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.