| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:8986723, PubMed:9382884, PubMed:9862668). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (PubMed:8986723). May play a role in mast cell development (PubMed:9862668). . |
| GO - Molecular function |
- complement component C3b binding : IGI:ARUK-UCL
- heat shock protein binding : ISO:MGI
- heparan sulfate proteoglycan binding : IDA:MGI
- heparin binding : IDA:MGI
- metal ion binding : IEA:UniProtKB-KW
- opsonin binding : IDA:MGI
- protein heterodimerization activity : ISO:MGI
|
| GO - Biological process |
- activated T cell proliferation : IMP:MGI
- amyloid-beta clearance : IMP:ARUK-UCL
- cell adhesion : IMP:MGI
- cell-cell adhesion : IGI:MGI
- cellular extravasation : IMP:MGI
- integrin-mediated signaling pathway : IEA:UniProtKB-KW
- leukocyte adhesion to vascular endothelial cell : IMP:UniProtKB
- leukocyte cell-cell adhesion : IMP:MGI
- leukocyte migration involved in inflammatory response : IMP:MGI
- microglia development : IDA:MGI
- microglial cell activation : IMP:ARUK-UCL
- negative regulation of dopamine metabolic process : IDA:ARUK-UCL
- neutrophil apoptotic process : IMP:UniProtKB
- neutrophil chemotaxis : IMP:MGI
- phagocytosis : IMP:UniProtKB
- phagocytosis, engulfment : IMP:ARUK-UCL
- positive regulation of mast cell differentiation : IMP:UniProtKB
- positive regulation of microglial cell activation : IMP:ARUK-UCL
- positive regulation of neuron death : IMP:ARUK-UCL
- positive regulation of neutrophil degranulation : ISO:MGI
- positive regulation of oxidative stress-induced neuron death : IMP:ARUK-UCL
- positive regulation of prostaglandin-E synthase activity : IMP:ARUK-UCL
- positive regulation of protein targeting to membrane : IMP:ARUK-UCL
- positive regulation of superoxide anion generation : IMP:ARUK-UCL
|