Farnesyl pyrophosphate synthase (P05369)

Uniprot ID P05369
Protein Name Farnesyl pyrophosphate synthase
Gene Name Fdps
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). .
GO - Molecular function
  • dimethylallyltranstransferase activity : IBA:GO_Central
  • geranyltranstransferase activity : IDA:RGD
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • cellular response to fatty acid : IEP:RGD
  • cholesterol biosynthetic process : TAS:RGD
  • farnesyl diphosphate biosynthetic process : IDA:RGD
  • geranyl diphosphate biosynthetic process : IEA:UniProtKB-UniPathway
  • isoprenoid biosynthetic process : IDA:RGD
  • male gonad development : IEP:RGD
  • positive regulation of cell growth involved in cardiac muscle cell development : IMP:RGD
  • positive regulation of cholesterol biosynthetic process : IMP:RGD
  • response to cholesterol : IEP:RGD
  • response to drug : IEP:RGD
  • response to peptide hormone : IEP:RGD
  • response to testosterone : IEP:RGD
  • spermatogenesis : IEP:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.