| Signal peptide(a) |
Y |
Secretome P(b) |
0.886 |
| Function |
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
| GO - Molecular function |
- cytokine activity : IDA:BHF-UCL
- growth factor activity : IDA:BHF-UCL
- interleukin-6 receptor binding : IPI:BHF-UCL
|
| GO - Biological process |
- acute-phase response : TAS:BHF-UCL
- cellular protein metabolic process : TAS:Reactome
- cellular response to hydrogen peroxide : IDA:BHF-UCL
- cellular response to lipopolysaccharide : IMP:MGI
- cytokine-mediated signaling pathway : IDA:BHF-UCL
- defense response to Gram-negative bacterium : TAS:BHF-UCL
- defense response to Gram-positive bacterium : TAS:BHF-UCL
- defense response to virus : IDA:BHF-UCL
- endocrine pancreas development : ISS:BHF-UCL
- glucagon secretion : ISS:BHF-UCL
- hepatic immune response : IDA:BHF-UCL
- humoral immune response : IC:BHF-UCL
- inflammatory response : IDA:BHF-UCL
- interleukin-6-mediated signaling pathway : IDA:BHF-UCL
- monocyte chemotaxis : IC:BHF-UCL
- negative regulation of apoptotic process : IDA:UniProtKB
- negative regulation of bone resorption : ISS:BHF-UCL
- negative regulation of cell proliferation : TAS:ProtInc
- negative regulation of chemokine biosynthetic process : ISS:UniProtKB
- negative regulation of collagen biosynthetic process : IDA:BHF-UCL
- negative regulation of fat cell differentiation : NAS:BHF-UCL
- negative regulation of interleukin-1-mediated signaling pathway : ISS:BHF-UCL
- negative regulation of lipid storage : NAS:BHF-UCL
- neuron projection development : IMP:BHF-UCL
- neutrophil apoptotic process : IDA:UniProtKB
- neutrophil mediated immunity : TAS:BHF-UCL
- platelet activation : TAS:BHF-UCL
- positive regulation of acute inflammatory response : IDA:BHF-UCL
- positive regulation of apoptotic process : IDA:UniProtKB
- positive regulation of B cell activation : IDA:BHF-UCL
- positive regulation of cell proliferation : IDA:BHF-UCL
- positive regulation of chemokine production : IDA:BHF-UCL
- positive regulation of DNA binding transcription factor activity : IDA:BHF-UCL
- positive regulation of gene expression : IDA:BHF-UCL
- positive regulation of immunoglobulin secretion : IDA:BHF-UCL
- positive regulation of interleukin-6 production : IDA:BHF-UCL
- positive regulation of JAK-STAT cascade : IDA:BHF-UCL
- positive regulation of leukocyte chemotaxis : TAS:BHF-UCL
- positive regulation of MAPK cascade : IDA:BHF-UCL
- positive regulation of osteoblast differentiation : TAS:BHF-UCL
- positive regulation of peptidyl-serine phosphorylation : IDA:MGI
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:MGI
- positive regulation of smooth muscle cell proliferation : IDA:BHF-UCL
- positive regulation of T cell proliferation : IDA:BHF-UCL
- positive regulation of T-helper 2 cell cytokine production : ISS:BHF-UCL
- positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL
- positive regulation of transcription, DNA-templated : IDA:UniProtKB
- positive regulation of translation : IDA:UniProtKB
- positive regulation of type B pancreatic cell apoptotic process : TAS:BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein : IDA:BHF-UCL
- post-translational protein modification : TAS:Reactome
- regulation of angiogenesis : IC:BHF-UCL
- regulation of vascular endothelial growth factor production : IDA:BHF-UCL
- response to glucocorticoid : IDA:BHF-UCL
- response to peptidoglycan : NAS:BHF-UCL
- T-helper 17 cell lineage commitment : ISS:UniProtKB
|